𝐖𝐡𝐚𝐭 𝐢𝐟 the generation of intestinal #organoids could be more precise and predictable for clinical applications? Ella Hushka and colleagues make a big step in this direction in their #preprint on BioRxiv. 𝐖𝐡𝐚𝐭 𝐝𝐢𝐝 𝐭𝐡𝐞𝐲 𝐝𝐨? ✅ Synthesized borate ester- based hydrogels using polyethylene glycol (PEG) macromers and encapsulated intestinal organoids as colonies within the synthetic hydrogel. ✅ Evaluated the viability, crypt formation efficiency (CFE) and crypt architecture. 𝐖𝐡𝐚𝐭 𝐝𝐢𝐝 𝐭𝐡𝐞𝐲 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫? ✅ The borate ester hydrogels rapidly relaxed matrix stress to levels comparable to standard Matrigel. ✅ Unlike with other synthetic matrices, the matrix used in this study did not need to be supplemented with laminin to robustly produce crypts at high CFE. In fact, the organoids in this synthetic matrix could deposit their own laminin to guide crypt formation. ✅ Extracellular matrix (ECM) and other protein deposition was influenced by matrix viscoelasticity, with a higher ECM deposition occurring in a viscoelastic matrix, as opposed to an entirely elastic matrix. This work is significant as it demonstrates the robust generation of intestinal organoids without the usage of biologically undefined matrices such as Matrigel. While more characterisation and development are required, this is a step forward towards the development of intestinal organoids for drug development and clinical studies. 𝐑𝐞𝐚𝐝 𝐭𝐡𝐞 𝐟𝐮𝐥𝐥 𝐩𝐚𝐩𝐞𝐫 𝐡𝐞𝐫𝐞: https://lnkd.in/eNWDZfNK At BioMed X Institute we aim to identify novel transport mechanisms in the human intestine that could be targeted for oral systemic delivery of therapies. To achieve this objective, Team #TMI generates intestinal organoids from human and murine tissue to establish a co- culture system for monitoring drug delivery across the intestinal barrier. The final goal is to create a novel delivery platform to develop a new generation of oral therapies for patients. Kyungbo Kim | Enrique Gamero Estévez, PhD | Praveen Nattramilarasu | Olivia Amanda Oest Müllertz | Elizaveta Savochkina #organoids #bioavailability #drugdiscovery
BioMed X Institute
Biotechnologieforschung
Biomedical innovation at the interface between academia and industry
Info
BioMed X is an independent research institute located on the campus of the University of Heidelberg in Germany, with a world-wide network of partner locations. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowdsourcing with local incubation of the world’s brightest early-career research talents. Each of the highly diverse research teams at BioMed X has access to state-of-the-art research infrastructure and is continuously guided by experienced mentors from academia and industry. At BioMed X, we combine the best of two worlds – academia and industry – and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun.
- Website
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https://bio.mx
Externer Link zu BioMed X Institute
- Branche
- Biotechnologieforschung
- Größe
- 51–200 Beschäftigte
- Hauptsitz
- 69120
- Art
- Privatunternehmen
- Gegründet
- 2013
- Spezialgebiete
- Biotech, research, pharma, innovation und AI
Orte
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Primär
Im Neuenheimer Feld 515
69120, Heidelberg, DE
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55 Church St
New Haven, Connecticut 06510, US
Beschäftigte von BioMed X Institute
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Thomas Rueckle
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Christian Tidona
Incurably Curious | BioMed X Institute | XSeed Labs | Building world-class innovation ecosystems for biomedical research, drug discovery and…
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Eleonora Melzi
Group Leader - Immunologist
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Gorjana Rackov
BioMed X Institute | Spanish National Centre for Biotechnology CNB-CSIC
Updates
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BioMed X Institute hat dies direkt geteilt
🎉 EuroSTEMPeers 2024 Panel Discussions Recap! 🎉 We had a fantastic EuroSTEMPeers 2024 conference featuring several insightful panel discussions. We’d love to hear your feedback! Please fill out our survey: https://lnkd.in/eehT9jJv Panel: Ecosystem Support for Entrepreneurship 💡 Highlighted regional support systems in fostering biotech and life science startups. Key takeaways included tailored mentorship, accelerator programs, specialized funding, and educational courses. Public funding and support for international founders were also discussed. Moderator: Arindam Dey, Panelists: Ann-Kristin Mueller, Friedemann Loos, Mathis Palm, Katharina Klotzbach, Julia Piechotta Panel: Sustaining Future Innovation in Lifesciences, Biotech, and Pharma 💡 Highlighted that sustaining innovation requires continuous effort, robust infrastructure, and collaboration. Key points included the importance of enablers like BioLabs, BioMed X Institute, and other industry partners for innovation. Emphasis was on navigating regulations, ensuring safety, managing IP, realistic plans, and continuous learning. Moderator: Jubin Shah, Panelists: Christian Tidona, Boris Brik, Heena Khatter, Kurchi Bhattacharya, Ann-Kristin Mueller Panel: Expansive Career Prospects for Scientists 💡 Highlighted various roles for scientists within and outside academia. Key points included upskilling with new technologies, enhancing business acumen, and developing skills like strategic thinking, adaptability, networking, and handling failure. Moderator: Eshita Mutt, Panelists: Klara Giessler, Indrabahadur Singh, Swati Chandna Panel: Navigating the Recruitment Process 💡 Highlighted that landing your first industry job outside academia starts with introspection using the SMART method. Applying to interesting jobs, even if you don’t meet all criteria, was encouraged. Conducting informational interviews, asking specific questions, and effective networking were key points. Moderator: Sreemukta Acharya Panelists: Marion Gürth, Jubin Shah, Sachindra, Rita Freischlad Panel: Strategies in Mid-Career Advancement 💡 Highlighted continuous learning and skill enhancement, such as pursuing advanced degrees or certifications. Seeking leadership or specialized roles and expanding professional networks were crucial for navigating career opportunities. Moderator: Mayur Vadhvani Panelists: Pradnya Ladde, Sneha Kumar, Pablo-David A big thank you to our sponsors and partners for making this event possible: BioLabs Heidelberg (Co-organizer), BioMed X Institute, Heidelberg Innovation Park, hei_INNOVATION, Thermo Fisher Scientific, Techniker Krankenkasse, NEXT MANNHEIM, BioRN Life Science Cluster Rhine-Neckar, Boehringer Ingelheim #OpnME, Sci-Illustrate, Endosymbiont, Catenion If you have any questions, feel free to connect with the panelists or reach out to the moderators to facilitate the connection. Your engagement is vital to us!
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🔵 Last week, a group of 𝘤𝘶𝘳𝘪𝘰𝘶𝘴 BioMed X fellows traveled to #Mainz to attend the #CURIOUS2024 conference, organized by Future Insight e.V. 🔵 The conference - described by some as the "Woodstock of science" -gathered Nobel Prize winners, researchers, biotech companies, and NGOs under the same roof guided by the slogan "𝒖𝒏𝒊𝒕𝒆𝒅 𝒃𝒚 𝒔𝒄𝒊𝒆𝒏𝒄𝒆". 🔵 From the latest research in neurodegenerative diseases, to thinking-outside-the-box proposals like building floating cities on the ocean, CURIOUS2024 was rich in surprising topics, a diversity of attendees, and industry partners showcasing their work. 🔷🔷 Thank you for having us! See you again in 2026! 🔷🔷 Iris Potakowskyj | Tomasz Stadler | Tamara Pfanner | César Pérez Bucio | Oskar Haeberlein | Dr. Janine Lückgen | Douglas McCloskey | Flavia-Bianca Cristian | Christian Tidona | Thomas Rueckle | Yvonne Stappenbeck Future Insight e.V. | BioMed X Institute | BioRN Life Science Cluster Rhine-Neckar #UnitedByScience #SciComm #WissKomm
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It was fantastic to have our first #transatlantic group leader meeting in our BioMed X Institute US! Alicia Cutler, Lorenzo Talà and Khulan Sergelen had scintillating scientific discussions and even found the time for some sightseeing in #NewHaven. Mark Johnston | John Lindner | Christian Tidona
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BioMed X Institute hat dies direkt geteilt
Proud to have co-organized #EuroSTEMPeers2024 with EuroSTEMPeers in Heidelberg! 🧬🔬💡 What an incredible two days of knowledge sharing and connection building. As BioLabs Heidelberg we aimed to create an environment where networking was just as valuable as the formal sessions - and the feedback has been phenomenal! Participants consistently highlighted how the program led to valueable insights around carreer, growth, entrepreneurship, personal development and networking Some highlights: • Engaging talks on academia-to-industry transitions • Interactive workshops on negotiation skills, stress management and design thinking • Thought-provoking panel discussions on entrepreneurship support and mid-career advancement • Invaluable networking sessions, including BioLab Tours (led by the BioLabs Heidelberg team (Ann-Kristin Mueller, Ornella Kossi, Heiner Sähr) It was inspiring to see so many connections being made between young professionals, researchers, industry professionals, and entrepreneurs. The energy and ideas exchanged during these interactions were truly the heart of the event. A huge thank you to all speakers, panelists, and especially the participants who made this conference a resounding success. And a shout-out to the EuroSTEMPeers team around Arindam Dey, PhD, Kuheli Banerjee, Dr. Sreemukta Acharya, Anshu Singh, PhD, Devika Srivastava, Ph.D., Eshita Mutt, PhD, Jagriti Pal, PhD, Jubin Shah, PhD, Dr. Mayur Vadhvani, Mugdha Kiran Dhurandhar, Nambirajan Govindarajan, Nandan Varadarajan, PhD, Priyanka, Rahul Ravichandran Ph.D., Santosh Lomada, PhD, Vinay Murtadak, Ph.D. Together, we're not just discussing the future of STEM - we're actively shaping it. And in addition a heartfelt thank you to all partners and sponsors of the event: BioMed X Institute, hip:com (Heidelberg Innovation Park), hei_INNOVATION, Thermo Fisher Scientific, Die Techniker, NEXT MANNHEIM, BioRN Life Science Cluster Rhine-Neckar, Boehringer Ingelheim #OpnME, Sci-Illustrate, Endosymbiont, Catenion Looking forward to the innovations and collaborations that will emerge from these two days! 🚀 #STEM #Innovation #Biotech #Networking #CareerDevelopment
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𝐖𝐡𝐚𝐭 𝐢𝐟 the resolution, cost and accessibility of spatial transcriptomics could be enhanced? #OpenST, a high resolution, 3D spatial transcriptomics (ST) tool developed by Marie Schott, 𝐃𝐚𝐧𝐢𝐞𝐥 𝐋, Elena Splendiani and colleagues and published in Cell Press could be the answer to this challenging question. 𝐖𝐡𝐚𝐭 𝐝𝐢𝐝 𝐭𝐡𝐞𝐲 𝐝𝐨? ✅ Repurposed Illumina’s sequencing flow cell into ST RNA capture areas. They utilised standard lab equipment and optimised the technique to keep costs low per capture area. ✅ Tested the efficacy of Open ST on mouse brain tissue, primary human head and neck tumours and patient matched healthy/ metastatic lymph nodes. ✅ Developed an open access bioinformatics pipeline to generate virtual 3D tissue blocks by combining ST and morphological information (H&E staining) of successive tissue sections. 𝐖𝐡𝐚𝐭 𝐝𝐢𝐝 𝐭𝐡𝐞𝐲 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫? ✅ Compared to competitors, Open ST demonstrated high transcript capture and efficient library amplification, thereby making it cost effective as deeper sequencing could be achieved with fewer reads. ✅ Open ST could capture transcripts at sub cellular resolution in murine tissue and identify differential cellular heterogeneity in human tissues. When #benchmarked against an imaging based, targeted ST platform (Xenium, 10X Genomics), Open ST yielded comparable data. ✅ The reconstructed virtual 3D tissue blocks could be used to correlate gene signatures to biological function and cellular location, demonstrating the potential to identify biomarkers in 3D. While Open ST is exciting due to its resolution and cost effectiveness, it has several limitations that need to be overcome before this technology can become the standard in spatial transcriptomics. 𝐑𝐞𝐚𝐝 𝐭𝐡𝐞 𝐟𝐮𝐥𝐥 𝐩𝐚𝐩𝐞𝐫 𝐡𝐞𝐫𝐞: https://lnkd.in/d7-y9wBX At BioMed X Institute, we use spatial transcriptomics and spatial proteomics tools to understand the cellular architecture of the human synovium in rheumatoid arthritis, the immune landscape of the human gut and the incidence of extrachromosomal DNA in cancer. These technologies enable the generation of new knowledge and drive our innovative preclinical research programme. 𝐅𝐢𝐧𝐝 𝐨𝐮𝐭 𝐦𝐨𝐫𝐞 𝐚𝐛𝐨𝐮𝐭 𝐨𝐮𝐫 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐭𝐞𝐚𝐦𝐬 𝐡𝐞𝐫𝐞: 𝐓𝐞𝐚𝐦 𝐏𝐓𝐀- https://lnkd.in/eXD5ep4E 𝐓𝐞𝐚𝐦 𝐓𝐌𝐈- https://lnkd.in/e6tAAMw5 𝐓𝐞𝐚𝐦 𝐄𝐃𝐂- https://lnkd.in/gKJuzhQw #Spatialomics #immunology #cancer
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See you 𝐭𝐨𝐦𝐨𝐫𝐫𝐨𝐰! ☕🌯 🥨 🍏 🍎 Join us tomorrow, 𝐓𝐡𝐮𝐫𝐬𝐝𝐚𝐲, 𝐉𝐮𝐥𝐲 11, at 11 𝐀𝐌, for a talk on 𝐮𝐧𝐜𝐨𝐧𝐯𝐞𝐧𝐭𝐢𝐨𝐧𝐚𝐥 𝐓 𝐜𝐞𝐥𝐥𝐬 𝐢𝐧 𝐠𝐮𝐭 𝐡𝐨𝐦𝐞𝐨𝐬𝐭𝐚𝐬𝐢𝐬 & 𝐝𝐢𝐬𝐞𝐚𝐬𝐞 by Dr. Francesco Strati from the Università degli Studi di Milano-Bicocca, Italy. 🍎 As always, this #LunchTalk will take place at the DKFZ German Cancer Research Center Communication Center (K1/K2). 🍎 Find out more about our speaker here: https://lnkd.in/gAebQwT7. 🍎 The Lunch Talk series is a collaboration between the BioMed X Institute and the DKFZ Postdoc Network (PDN). #Heidelberg #DKFZ #ScienceTalks #Tcells
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🌅 At least once a year, all #BioMed_X fellows are in the same place, at the same time! During our annual BioMed X Institute retreat, we all come together in a lovely place, away from the institute, for two days full of creativity, science, and fun! 🌅 This year, science updates were interspersed with team-building activities, photo shoots, discussions about the future of #AI, a myriad of games, and even an enthusiastic karaoke session! 🌅 The winners of the 𝐁𝐞𝐬𝐭 𝐓𝐚𝐥𝐤 & 𝐁𝐞𝐬𝐭 𝐏𝐨𝐬𝐭𝐞𝐫 awards have the privilege of attending the #Curious2024 (Future Insight e.V.) conference later this week. Congratulations & enjoy your prize! 🌅 Special thanks to the 𝐑𝐞𝐭𝐫𝐞𝐚𝐭 𝐂𝐨𝐦𝐦𝐢𝐭𝐭𝐞𝐞 2024 for making this a fun and memorable event for all of us! We are already looking forward to the 2025 BioMed X Institute retreat! Mallory Grahnert | Merve P. | Swathi Lingam | Praveen Nattramilarasu | Dr. Janine Lückgen | Alexandros Drainas | Kyungbo Kim | Yvonne Stappenbeck | John Lindner 𝐁𝐞𝐬𝐭 𝐏𝐨𝐬𝐭𝐞𝐫 𝐀𝐰𝐚𝐫𝐝 𝐖𝐢𝐧𝐧𝐞𝐫𝐬 Iris Potakowskyj, César Pérez Bucio 𝐁𝐞𝐬𝐭 𝐓𝐚𝐥𝐤 𝐀𝐰𝐚𝐫𝐝 𝐖𝐢𝐧𝐧𝐞𝐫𝐬 Tamara Pfanner, Tomasz Stadler, Kun-Yi Lai #TeamBuilding #ScienceGames #PhDLife
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𝐋𝐮𝐧𝐜𝐡 & 𝐋𝐞𝐚𝐫𝐧! 🥐 🥑 🌯 ☕ 🍎 🥨 Mark your calendars to join our #LunchTalk this Thursday, to learn about 𝐮𝐧𝐜𝐨𝐧𝐯𝐞𝐧𝐭𝐢𝐨𝐧𝐚𝐥 𝐓 𝐜𝐞𝐥𝐥𝐬 𝐢𝐧 𝐠𝐮𝐭 𝐡𝐨𝐦𝐞𝐨𝐬𝐭𝐚𝐬𝐢𝐬 and 𝐝𝐢𝐬𝐞𝐚𝐬𝐞 from Dr. Francesco Strati from the Università degli Studi di Milano-Bicocca, Italy. 🥨 The talk will take place at the DKFZ German Cancer Research Center Communication Center (K1/K2) at 11 AM, on Thursday, July 11. 🥨 The Lunch Talk series is organized by the BioMed X Institute in collaboration with the DKFZ Postdoc Network (PDN). More information about our Lunch Talk events here: https://lnkd.in/e-KTckBC. 🥨 Questions or suggestions? Please leave them in the comments section below.
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#WelcomeToBioMedX We are happy to welcome 𝐀𝐧𝐢𝐥 𝐊𝐮𝐦𝐚𝐫 𝐏𝐚𝐥, our new senior scientist in team BDB – Advanced #Biomarker Detection for Pharmacological Monitoring in the #Brain. Anil is originally from #Cuttack, India. He has done master’s and PhD in #Physics from Pondicherry University, India, in the #Plasmonics research group lead by 𝐏𝐫𝐨𝐟. 𝐃. 𝐁𝐡𝐚𝐫𝐚𝐭𝐡𝐢 𝐌𝐨𝐡𝐚𝐧. Upon completing his doctoral studies, he worked as a postdoctoral fellow at the University of Birmingham. Prior to joining the BioMed X Institute, Anil was a #Humboldt Fellow in 𝐏𝐫𝐨𝐟. 𝐒𝐭𝐞𝐟𝐚𝐧 𝐌𝐚𝐢𝐞𝐫'𝐬 group at Ludwig-Maximilians-Universität München (Ludwig Maximilian University of Munich) in Munich, Germany. Throughout his research career, Anil has focused on plasmonic #nanostructures and various types of optical #biosensors, including SERS, diffractive, and leaky waveguide sensors. Welcome, Anil, and good luck! Are you interested in #career opportunities at the interface between #academia and #industry? Take a look at the BioMed X Institute Career Space: https://bio.mx/career. Khulan Sergelen | Cátia Santa | Soohyun Park | Pragnya Satapathy
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