San Francisco, California, United States
Contact Info
2K followers
500+ connections
Activity
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We are excited to announce that world-class investors are joining us to advance ASN51 into Phase 2 for Alzheimer's disease patients. Tau…
We are excited to announce that world-class investors are joining us to advance ASN51 into Phase 2 for Alzheimer's disease patients. Tau…
Liked by Bryan Faust, PhD
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A publication highlighting Nido's research, resulting in a robust and novel set of fluid protein biomarkers in spinal and bulbar muscular atrophy…
A publication highlighting Nido's research, resulting in a robust and novel set of fluid protein biomarkers in spinal and bulbar muscular atrophy…
Liked by Bryan Faust, PhD
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🚨🚨 MYRICX MEGAROUND! Congratulations to Robin Carr and team for raising a £90m ($114m) Series A to progress their pipeline of NMTi-based ADCs to…
🚨🚨 MYRICX MEGAROUND! Congratulations to Robin Carr and team for raising a £90m ($114m) Series A to progress their pipeline of NMTi-based ADCs to…
Liked by Bryan Faust, PhD
Experience & Education
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Andreessen Horowitz
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Publications
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Autoantibody mimicry of hormone action at the thyrotropin receptor
Nature
See publicationBiophysical characterization (cryo-EM and all-atom molecular dynamics) and pharmacological interrogation of hormone and autoantibody mediated conformational control at the human Thyrotropin receptor.
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Selective G protein signaling driven by substance P–neurokinin receptor dynamics
Nature Chemical Biology
See publicationCryo-EM, molecular dynamics, and in vitro signaling experiments reveal the importance of the full complement of neuropeptide contacts at the Neurokinin receptor (NK1R) for balanced G protein signaling. Disruption of neuropeptide:extracellular loop contacts diminishes Gs, but not Gq, activation by NK1R.
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Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia
Cell
See publicationBiophysical characterization of SARS-CoV-2 neutralizing antibodies that not only block Spike-mediated viral entry but also modulate Spike-mediated syncytia formation.
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An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Science
See publicationDiscovery, characterization, and structure guided engineering of single-domain antibodies capable of eliciting conformational control of SARS-CoV-2 Spike proteins as a means to elicit passive immunity against COVID-19.
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Lipid Nanodiscs via Ordered Copolymers
Chem - CellPress
See publicationDevelopment of amphipathic co-polymers for improved extraction and solubilization of membrane proteins in "native" nanodiscs.
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Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding
ACS Chemical Biology
See publicationDeep mutational scanning to investigate how a toxic conformation of α-synuclein, a dynamic protein linked to Parkinson’s disease, responds to perturbations of cellular proteostasis.
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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
Nature
See publicationProposes a model for activation of Smoothened, a class F GPCR implicated in embryonic development, via sterol occupancy in the orthosteric binding site.
Languages
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Spanish
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More activity by Bryan
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I'm starting a company. We are building autonomous agents that can reason over the sum total of biomedical knowledge. Thousands of decisions behind…
I'm starting a company. We are building autonomous agents that can reason over the sum total of biomedical knowledge. Thousands of decisions behind…
Liked by Bryan Faust, PhD
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Precision obesity medicine! Excited to onboard and include Alfie Health technology in knownwell’s comprehensive clinical service offering…
Precision obesity medicine! Excited to onboard and include Alfie Health technology in knownwell’s comprehensive clinical service offering…
Liked by Bryan Faust, PhD
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C'mon people, let's give Matt Donne some $upport! A great guy and an even better cause!
C'mon people, let's give Matt Donne some $upport! A great guy and an even better cause!
Liked by Bryan Faust, PhD
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Delighted to be working with Peter Emtage Ph.D. and the Santa Ana Bio, Inc. team as they bring advanced biologic medicines to patients with a wide…
Delighted to be working with Peter Emtage Ph.D. and the Santa Ana Bio, Inc. team as they bring advanced biologic medicines to patients with a wide…
Liked by Bryan Faust, PhD
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Excited to announce that Santa Ana Bio came out of stealth and raised its series B!
Excited to announce that Santa Ana Bio came out of stealth and raised its series B!
Liked by Bryan Faust, PhD
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It’s a bad day to be a pathogenic immune cell. Congratulations to the newest a16z Bio + Health portfolio company, Santa Ana Bio, Inc., on their…
It’s a bad day to be a pathogenic immune cell. Congratulations to the newest a16z Bio + Health portfolio company, Santa Ana Bio, Inc., on their…
Shared by Bryan Faust, PhD
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📢📢NEW FUND! We are extremely happy to announce the first close of our new fund, Brandon Capital VI. The initial close is A$270m (US$180m) and will…
📢📢NEW FUND! We are extremely happy to announce the first close of our new fund, Brandon Capital VI. The initial close is A$270m (US$180m) and will…
Liked by Bryan Faust, PhD
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Excited to share a bit more about why we led the seed and co-led the series A at Valar Labs today! Valar is led by exceptional founders: Anirudh…
Excited to share a bit more about why we led the seed and co-led the series A at Valar Labs today! Valar is led by exceptional founders: Anirudh…
Liked by Bryan Faust, PhD
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