Senior Research Associate, Protein Expression

About Generate:Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with over 300 employees.

The Role:

Generate Biomedicines is seeking a highly motivated Senior Research Associate, Protein Expression to join our Large-scale Biotherapeutics Production Team. This individual will play a central role in supporting Generate’s discovery portfolio by producing plasmid DNA constructs, performing transient and stable cell transfections, and delivering therapeutic protein production batches. The successful candidate will be creative, self-motivated, and independent. This is a unique opportunity to work across a wide range of protein expression systems and therapeutic protein modalities in a discovery-minded, cross-functional, and team-oriented setting.

Here's how you will contribute:

• Perform plasmid DNA cloning using contemporary techniques including Gibson and Golden Gate Assembly
• Produce transfection quality DNA using standard and high throughput methods
• Characterize and QC DNA batches using Sanger and NGS sequence analysis
• Transfect mammalian cells using lipofection and electroporation
• Perform protein expression batches in deep-well plates, shake flasks, microbioreactors, and benchtop bioreactors
• Assess protein batches for titer and product quality
• Represent the Large-scale Biotherapeutics Production Team at program meetings
• Work closely with downstream partners to ensure timely delivery of harvest material
• Maintain meticulous records and registries of DNA, protein, and cell line batches in the laboratory information system (LIMS)
• Carefully and comprehensively record experimental results in electronic laboratory notebook (ELN)

The Ideal Candidate will have:

• MSc degree in a scientific field of study and 2 years of relevant scientific experience in a biotech/pharma setting; or a BSc degree in a scientific field of study and 4 years of related experience; or 7 years of related experience.
• Hands-on experience in industry setting
• A meticulous nature with attention to detail
• A self-starter attitude with the ability to take initiative
• Excellent communication, documentation, and technical writing skills
• The ability to solve problems and work independently

Location: Andover, MA (Primary) and Somerville, MA (30%)

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate:Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The Company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.

Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.