New research from Lipids: Acute ultraviolet B irradiation increases cholesterol and decreases Cyp7a1 expression in the liver of female mice
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𝐔𝐧𝐥𝐨𝐜𝐤𝐢𝐧𝐠 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐏𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 in Recombinant Antibodies, Precision Medicine, and Drug Discovery | Advancing Multi-Omics and Immunotherapy Innovations Through Meaningful Collaborations
Exciting research in immunology! 🧬 Researchers investigated the diurnal variations of VAT Tregs and the impact of core-clock genes on their function. Findings highlight the role of circadian rhythms in optimizing VAT Treg function and metabolic processes. Learn more about this study here: https://lnkd.in/e8ycDzCc #Immunology #CircadianRhythms #Science #Treg #Metabolism 🌟
Tregs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis
science.org
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Ectopic Thyroid Glands Restore Hormone Regulation Study authors from Nanjing University detail a method involving transplanting blocks of thyroid tissue to the spleen to regenerate thyroid glands and restore full thyroid function in mice. #hormone #thyroid
Ectopic Thyroid Glands Restore Hormone Regulation
genengnews.com
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🎇 Lear more about Gut Microbiota Modulation and Fecal Transplantation in this #editorschoice #review 👥 Ramzi Hassouneh and Jasmohan S. Bajaj 🔗 Full text: https://lnkd.in/d2ga5Uki #clinical #medicine #openaccess #gutmicrobiota #transplantation 📑 This article belongs to the Special Issue Hepatic Encephalopathy: Clinical Challenges and Opportunities
Gut Microbiota Modulation and Fecal Transplantation: An Overview on Innovative Strategies for Hepatic Encephalopathy Treatment
mdpi.com
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In patients with #multiple_sclerosis, there are specific oral microbiota and metabolites as potential biomarkers that may additionally be associated with a causal relationship (pathogenicity). NOTES: - Oral #Ammonium, which is a potent #neurotoxic compound, was more common in the oral cavity of MS patients. - MS models predicted a large increase in the production of #Methanol and #Formaldehyde, and a decreased availability of #Inosine and #Deoxyinosine. - Known for its cancerogenic properties, Formaldehyde was also reported to play a role in neurological disorders - #Myoinositol and #Deoxycytidine showed decreased bioavailability in MS patients. - Myoinositol is an important cell messenger and osmolyte in the nervous system. - Deoxycytidine is a hypomethylating agent, that has promising protective effects and is capable of improving the course of EAE. - Inosine was shown to improve cognitive function and to decrease neuroinflammation in ageing rats. - In Ms > A significant decrease in #Spermidine synthase by the gut microbiota, as well as a decrease in components of the norspermidine biosynthesis pathway in the saliva was observed. - The abundance of #Actinomyces genus, along with several #Actinomycetales compounds increased in the gut of MS patients. - There is a peptide from #Actinomyces can mimic #Collagen type IV α3127–148 and become a source of #autoimmunity, thus leading to anti-glomerular basement membrane disease in HLA DRB1*15:01 humanized mice - Among the oral microbiota, five genera (#Dialister, #Aggregatibacter, #Catonella, #Streptococcus, and #Paludibacteriaceae-F0058) had a decreased relative abundance in the MS cohort. Interestingly, the first three genera have also been shown to be associated with periodontal diseases - the #Enterobacteriaceae family (including #Escherichia, #Shigella, #Enterobacter and others) exhibited a large increase in abundance in the MS group - #HycI_peptidase, an enzyme from #Escherichia_coli that acts as a pH resistance factor (pH 2–2.5)29, was more abundant in MS. - #Fusobacterium and #Leptotrichia had an increased abundance in the MS oral microbiota. MyNote: Consider always oral hygiene in MS as with any other neurodegenerative disease. https://lnkd.in/ejtkN88d
Investigating the metabolite signature of an altered oral microbiota as a discriminant factor for multiple sclerosis: a pilot study - Scientific Reports
nature.com
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https://lnkd.in/g8JyXMgY Article title: The effect of physical load of varying intensity on the activity of liver enzymes and hepatocytes’ proliferation Author(s): II Malyshev*, LP Romanova and OV Vorobeva Journal: Open Journal of Hepatology Journal ISSN: 2994-4287 Abstract: The paper establishes the relationship between enzymatic activity and the proliferation of hepatocytes. Low-intensity physical activity is shown not to influence the activity of hepatocytes’ enzymes and their proliferation. Hard work results in decreased activity of redox enzymes; at the same time, the proliferation of hepatocytes is inhibited for a long time. The most favorable is moderate load, which leads to the activation of oxidative-reducing enzymes and increases the number of binucleated hepatocytes, which persist for a long time after the end of the experiment. #Liver #Enzymes #Hepatocytes #Proliferation #PhysicalActivity #Mitoses #Peertechz #PeertechzPublications #ChronicCholestaticLiverDiseases #CirrhosisAndItsComplications #DrugInducedLiverDisease #Autoimmune #FattyLiverDisease #GeneticAndPediatricLiverDiseases #HepatocellularCarcinoma #HSCsAndFibrosis #LiverImmunology #LiverRegeneration #LiverTransplantation #ViralHepatitisAAndE #ViralHepatitisBAndD #ViralHepatitisC #Cirrhosis #Jaundice #LiverCancer #HepaticEncephalopathy #HepatobiliaryDisease #Hepatotoxicity #LiverBiopsy #WilsonsDisease
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