CSBio’s Post

🔬 The Essential Role of pH Buffers in Scientific and Industrial Applications! pH buffers are indispensable tools in both scientific research and industrial processes, providing the stability needed for accurate and consistent pH measurements. They play a key role in various fields, including pharmaceuticals, biotechnology, and environmental science. Explore how pH buffers contribute to maintaining optimal conditions for reactions and processes, driving innovation and quality control across industries. 🌟🧪 #pHBuffers #Chemistry #Biotechnology #EnvironmentalScience #QualityControl Aladdin Scientific: https://lnkd.in/gK_3uq8a Aladdin official：https://lnkd.in/gpz_mD7p

🔬 The Essential Role of pH Buffers in Scientific and Industrial Applications! pH buffers are indispensable tools in both scientific research and industrial processes, providing the stability needed for accurate and consistent pH measurements. They play a key role in various fields, including pharmaceuticals, biotechnology, and environmental science. Explore how pH buffers contribute to maintaining optimal conditions for reactions and processes, driving innovation and quality control across industries. 🌟🧪 #pHBuffers #Chemistry #Biotechnology #EnvironmentalScience #QualityControl Aladdin Scientific: https://lnkd.in/gVFbuRU4

You must have heard that #bacteria 🦠 can be used to make many of the future's products... it sounds ludicrous, but it is true! For example, in the picture below [1], you see Cupriavidus necator cells with bright spots inside them. These are granules of Polyhydroxybutyrate (PHB), a #biodegradable #bioplastic ♻️ PHB is not just an academic curiosity; it already finds uses in #biomedicine and #pharmacology, and will likely become increasingly ubiquitous as a bioplastic 📈 Producing this bioplastic is not limited to C. necator cells. It can also be made by other bacteria such as the extremophilic bacterium, Kyrpidia spormannii, which our colleague Leonie Rominger is researching 👩🔬 Excitingly, PHB-producing bacteria, such as C. necator, can be engineered to produce other #bioproducts instead of PHB 🧬 For example, some of our scientists have engineered C. necator to produce platform #chemicals such as acetoin and butanediol [2] 🧪 The next step, naturally, is to produce these #sustainable bioproducts at larger and more relevant scales, which is what we are already working on in our EveryCarbon project 😎 Follow our page if you want to know more about our #research specialties in #microbiology and #biotechnology [1] Tian et al., J. Bacteriol., 2005 [2] Knoll, M., Weiler, J., & Gescher, J. (2022). Produktion von Plattformchemikalien durch mikrobielle Biokatalysatoren. BIOspektrum, 28(3), 338-340.

🎉 Exciting News from ASA BIOTECH! 🎉 We're thrilled to share a significant achievement in the realm of biotechnology! ASA Biotech, as the official representative of Hanbon Company in #Iran, is delighted to announce the successful installation of the "Biolab 300 chromatography system" in the research and development department of AryoGen Pharmed Company. 🌐 About Biolab 300 Chromatography System: Bio-Lab 300 chromatography system is a highly efficient, fast, and reliable automatic chromatography device independently developed by Hanbon, which can be used for the rapid purification of biological molecules such as protein, polypeptides, and nucleic acids from micrograms to grams. 🔍 Key Features: ·       Rapid purification of #proteins, #peptides, #nucleic #acids, and other #biological molecules from microgram to gram levels. ·       Modular design and intelligent software for versatility in meeting purification requirements for various biological #macromolecules in the laboratory. ·       Suitable for the #purification of biomolecules from microgram to milligram levels, compatible with all kinds of pre-packed or small-volume chromatography columns. ·       Ideal for small-scale protein purification. 💡 At ASA Biotech, we remain dedicated to fostering advancements in biotechnology and are honored to contribute to the success of our partners. This accomplishment marks a significant step forward in our mission to provide state-of-the-art solutions to the biotech industry. #ASABiotech #Biotechnology #Innovation #Chromatography #pharmaceuticalindustry #Biolab300 #ResearchAndDevelopment #MilestoneAchievement

📢 📢 Excited to learn about bioconversion, whether it's through whole microbial cells or isolated enzymes? Register for our upcoming webinars at VITO on April 23rd and 25th to explore this fascinating world. Join us for insightful discussions and latest updates in this dynamic field chaired by Prof. Ludo Diels. #Bioconversion #Science #Innovation #Biocatalysis #Fermentation Heleen De Wever Marzio Monagheddu Winnie Dejonghe

💡 Organic chemistry literature spotlight 💡 A great achievement from the MacMillan's group in collaboration with Manuel Jesus Alcazar Vaca from The Janssen Pharmaceutical Companies of Johnson & Johnson: a new way to rapidly synthesize sp3-rich molecules from abundant feedstock via photocatalysis and NHC activation!! David W. C. MacMillan and coworkers developed a sp3-sp3 photocatalyzed coupling between two alcohols: ✅ Simultaneous activation of alcohols with NHC reagent. ✅ Radical sorting and C(sp3)–C(sp3) bond formation through bimolecular homolytic substitution (SH2). ✅ Coverage of large chemical space. ✅ Orthogonal functionalization governed by steric effect. ✅ Late-stage functionalization 👏 Congratulations to the authors: Ruizhe Chen et al., Alcohol-alcohol cross-coupling enabled by SH2 radical sorting. Science383, 1350-1357 (2024). DOI:10.1126/science.adl5890 ▶ https://lnkd.in/dtkSMxeW #organicchemistry #photochemistry #drugdiscovery #science Princeton University

🔍 #PROTAC new chemical scaffolds targeting CRBN🔬 Significant strides in optimizing protein degraders, a crucial avenue for targeted protein degraders. The focus of this research is on fine-tuning the chemical scaffold of cereblon (CRBN) binders, key players in manipulating the function of the E3 ligase. The study unveils a series of novel CRBN binding moieties, meticulously designed and synthesized. These binders were put to the test, and evaluated for their ability to bind with CRBN and degrade common neo-substrates Aiolos and GSPT1. The findings not only shed light on the depth of on-target degradation but also highlight the selectivity in degrading neosubstrates and other drug-like properties. A captivating aspect of the research involves using a selected set of these binders to create an exploratory series of heterobifunctional molecules. These molecules are designed to target CRBN-mediated degradation of the androgen receptor, opening up new possibilities in drug design. In essence, this research is a leap forward in the quest for diverse chemical scaffolds to target CRBN. Share, like, comment and follow Purushottam Dewang and MetaG1 Research Consortium #DrugDevelopment #Innovation #Research #Biotechnology #PROTACs #PROTAC #MetaG1 ref: 10.1021/acs.jmedchem.3c01848

I am happy to share that I have successfully presented my paper on "Gracilaria: A Review of its Bioactive Potential and Phylogenetic Diversity" at the Lloyd International Conference on Transformation Through Technology and Transdisciplinary Education. This conference was organized by Lloyd Institute of Management and Technology (Pharm.) in collaboration with various national and international organizations. I would like to thank my mentors, peers, and organizers for this wonderful opportunity and learning experience. #gracilaria #redalgae #bioactive #phylogeny #pharmacy #lloydconference #transdisciplinary #technology

📢 A new Special Issue "Biotechnological Advances in Industrial Enzymes and Green Bioprocessing" is now open for submissions! 🥼 This Special Issue is guest-edited by Dr. Hongchen Zheng, from Chinese Academy of Sciences, China; Dr. Guo-Qiang Chen, from Tsinghua University, China; and Dr. Xianpu Ni, from Shenyang Pharmaceutical University, China 💡 This Special Issue of Bioengineering addresses worldwide advances in biotechnology and bioengineering for promoting the rapid development of industrial enzymes and green bioprocessing in food industry, feed industry, agricultural field, pharmaceuticals industry, traditional light industries and other domains. 🔗 Click the link to access more details about the Special Issue: https://lnkd.in/gc55wfe2. 🕑 The deadline for manuscript submissions is 10 December 2024. 🎉 Welcome to join us as authors and reviewers! 👏 And welcome to follow our LinkedIn account: https://lnkd.in/grPNkBrg. #biotechnology #bioengineering #industrial #enzyme #engineering #protein #bioprocessing #microorganism #synthetic_biology #strain #metabolic_engineering