CSBio’s Post

A new open-access ‘aging atlas’ provides a detailed map of how cells and tissues age. Developed by the Wang Lab at HHMI’s Janelia Research Campus and collaborators at Baylor College of Medicine and Creighton University School of Medicine, the new atlas gives scientists an in-depth view of how individual cells and tissues in roundworms age and how different lifespan-extending strategies might stop the clock. 🔗 https://hhmi.news/3XrRWwe

Bridging clinical cutting-edge technology and new pre-clinical human-relevant model development   The adoption of cutting-edge technologies developed by clinicians back into pre-clinical research is a strategy that has started to be adopted only recently. Tissue engineering applied to e.g., regenerative medicine is one of the fields worthy of exploration by pre-clinical model developers. In fact, lab-grown tissues or, in some cases, entire organs starting from stem cells obtained by the same patient who will eventually receive the implant is now a well consolidated technology that allows to save many lives every year. One of the beauties of this technology is that the new lab-grown tissue/organ is not rejected by the patient, being it an autologous implant. From a pre-clinical perspective, the successful application of this technology in the clinics is a perfect proof of concept to argue the human relevance of a model developed with it! The next ambitious step will be to grow patient-derived stem cells on an artificial scaffold instead of a decellularized animal-derived scaffold. When I worked in UK, I had the privilege to meet Prof. Paolo De Coppi and to learn from him about the incredible potentialities of lab-grown tissues developed with this technology. Reconstructed human tissue models recapitulate many of the original tissue functionalities. Lab-grown human tissue development is a labor and time-consuming technology, as such, it will unlikely fit in the pre-clinical research speed; I hardly think it will ever become a high throughput technology but who knows!   https://lnkd.in/eyUawvyR

🎥 Meet Shifa Maherali Jiwani, a visionary researcher in the Summer Undergraduate Research Program (SURP) at Kennesaw State University! 🌟 Shifa's groundbreaking research explores arsenic's surprising potential as medicine! 💊 Her project focuses on discovering new arsenic-containing antibiotics, inspired by nature's own strategies against antibiotic-resistant pathogens. 🦠 Watch the video to witness Shifa's quest to combat antibiotic resistance and unlock new possibilities in medical science! 📽️

Keen to share that my paper on 'Construction of a Synthetic Colostrum Substitute and Its Protection of Intestinal Cells against Inflammation in an In Vitro Model of Necrotizing Enterocolitis' has now been published in ACS Applied Materials & Interfaces! This paper was based on my final set of experiments during my PhD, which couldn't have been made possible without my supervisors and guidance from my fellow peers Jae Pyun Jamie (Yuen Yi) Lam and Rekha Shandre.

One of the major challenges of lung bioengineering is developing new techniques for the repair and regeneration of injured lung tissue. One question I’m answering through my PhD is how to evaluate the extent to which I injure and recover lung tissue. To do that, we’ve developed a code to randomize selection of lung areas and standardize histological evaluation, which was just published on AJRCMB! It’s an easy and great tool for obtaining strong, unbiased data. 🫁🫁🫁 https://lnkd.in/eBJV8bgx

Regenerative medicine and autologous orthobiologics is one of the most progressive research fields in modern medicine. With new research published daily, it’s hard to keep up.   We’re here to help keep you informed on the best and most impactful research published each month in our Regenerative Research Roundup.   This month, we cover a number of exciting studies in the space of PRP and Adipose; including PRP for KOA, CADTH Reviews, and more!   Click below to read the research roundup: https://lnkd.in/g8XEMszx   #PRP; #regenerativemedicine; #orthobiologics #PlateletRichPlasma; #mdbiologix; #research #adipose

I’m glad to share our recent published paper about “Chronological analysis of periodontal bone loss in experimental periodontitis in mice”. https://lnkd.in/dHmN4jRp

The July issue of Current Opinion in Hematology is here! 🙌 Read the final version of this paper, Lipid mediators in neutrophil biology: inflammation, resolution and beyond, along with others in the Hematopoiesis section update from Maegan Capitano 👇 https://ow.ly/QV8550S1YvX ⭐ The role of hematopoiesis in bone repair: an update ⭐ The impact of obesity-induced inflammation on clonal hematopoiesis ⭐ Epigenetics of hematopoietic stem cell aging #hematology #hematopoiesis #reviews

🚨 New content coming soon! ⏰ This review from Anita Ghodsi, Andres Hidalgo and Stephania Libreros from Yale University focuses on recent advances in understanding the many functions of specialized pro-resolving mediators in neutrophil biology, from expediting neutrophil apoptosis, promoting clearance by macrophages, regulating their excessive infiltration at inflammation sites, to coordinating bone marrow deployment. You can check this out now online at the link below, published ahead-of-print! https://ow.ly/G3Ny50REyA7 Or make sure you are subscribed to our eTOC alert to be the first to know when our next issue is published! Visit the homepage for links to subscribe. Scroll down on our feed for screenshots of where to find these, or drop a comment below if you need a hand. 😀 Happy reading!

Now is your opportunity to listen to the inspiring lectures from the 2023 iCMLf Prize Winners! Watch their keynote presentations, which followed their award ceremony at the 25th John Goldman Conference on CML: Biology and Therapy. Hear first-hand from each recipient, as they share insights into their scientific and clinical work for CML over the past years. View the recordings here: https://bit.ly/3sAZtvU #CML #iCMLf #ESHCML2023