CSBio’s Post

High importance and widespread use of Fsp3 and FCstereo indicators in medicinal chemistry and their link to biologically relevant compound features is well known. However, they do not comprehensively express molecular topology, and they often do not match the chemical intuition of complexity. A new empirical scoring system termed the spacial score (SPS) can possibly overcome the existing limitation as it builds and improves upon the individual Fsp3 and FCstereo indicators by uniformly expressing spacial complexity on a highly granular scale for convenient ranking of and comparison between molecules. Furthermore, the SPS is an easy-to-calculate index that does not require information about the 3D conformation of a molecule and, when normalized, correlates to biologically relevant properties, including selectivity and potency. In addition, SPS can be used in the context of synthesis planning and analysis by directly comparing different chemical transformations and their impact on spacial arrangements and molecular complexity in the resulting product's molecular structures.

For an update on our capabilities in chiral chemistry technologies, including a couple of our most recent publications, click below. #chiralchemistry #organicchemistry #drugdevelopment #symeres

https://lnkd.in/gV7awgAa Article Title: Chemical and physical stability of selected drugs for aerosol therapy with Sirmione thermal water Author(s): Francesco Saverio Robustelli della Cuna, Carlo Sturani, Sarah Galfrè, Luisa Gervasio, Cristina Sottani and Elena Grignani   Journal: Open Journal of Chemistry Journal ISSN: 2641-3051 Abstract: In this work, we investigated the chemical and physical stability of ambroxol, beclomethasone dipropionate, budesonide and N-acetylcysteine after dilution with Sirmione thermal water, stored in ampoules for aerosol, at room temperature. The chemical stability of all active drugs was evaluated by Ultra-High-Performance Liquid Chromatography tandem mass spectrometry (UHPLC/MS/MS). All samples were analyzed in triplicate at room temperature under normal fluorescent light at 0h, 1h, 6h, 12h, and 24 h. According to the Official Pharmacopoeia of the Italian Republic, the degradation of a molecule that exceeds more than 10% is considered unacceptable. After dilution with thermal water of Sirmione, ambroxol, beclomethasone dipropionate, budesonide, and N-acetylcysteine, were found to be physically stable over the entire study (degradation <3%) at room temperature without any loss of activity.   #Sirmionethermalwater #Ambroxol #Beclomethasonedipropionate #Budesonide #Nacetylcysteine #Stability #Chemistry #OrganicChemistry #InorganicChemistry #PhysicalChemistry #AnalyticalChemistry #Biochemistry #TheoreticalChemistry #EnvironmentalChemistry #ChemicalEngineering #Peertechz #PeertechzPublications #PolymerChemistry #MedicinalChemistry #IndustrialChemistry #GreenChemistry #ChemicalSynthesis #ChemicalKinetics #Spectroscopy #Electrochemistry #Nanochemistry #SurfaceChemistry #QuantumChemistry #ChemicalBonding #Thermodynamics #ChemicalCatalysis #SupramolecularChemistry #MaterialsChemistry

The benefits of flow chemistry in applications related to antigens and antibodies span across more than just improved precision, productivity and scalability. In the life sciences, consistency and quality are valuable tools for research into the production of diagnostic, and therapeutic agents. Continuous flow is adaptive and scalable whilst maintaining highly controlled reaction parameters which means researchers can streamline their development processes. It can be applied in several ways to contribute to the production of antigens and antibodies in the life sciences, including: High throughput screening Peptide synthesis Solid phase synthesis Downstream processing Continuous separation and purification This is just another sector example whereby continuous flow production is playing a significant role in streamlining the manufacturing of essential materials. If you're interested in finding out more about the varying applications of flow chemistry, stay tuned! 👀 For now, you can speak to a member of our team to find out how continuous flow can transform your chemical processes at info@amt.uk #antibodyproduction #flowchemistry #continuousproduction

ACS Medicinal Chemistry Letters Most Read Articles - Transforming Therapeutic Approaches with PROTAC Technology: New Targets and Potentials (https://lnkd.in/gnX_K3Zp) Description: Most Read articles are refreshed daily and based on full text downloads (PDF and HTML) from the previous 30 days and 12 months. https://lnkd.in/gUqbUhP9

Early detection of 4-ethylphenyl sulfate (4-EPS), a gut microbial metabolite, in bodily fluids has huge implication in neurological and developmental disorders such as autism spectrum disorder (ASD). https://lnkd.in/g4xuc6ZF Our latest paper about the new method to detect 4‑ethylphenyl sulfate with enhanced sensitivity. #science #biotechnology #bioscience #microbiome #microbiology #metabolite #gutmicrobiome #gut #microbiota #biology #csir #drdo #dbt #dst #pharmaceutical #microbial #drugdiscovery #drugdevelopment #Biochemistry #biotech #biology #chemistry #college

Happy Wednesday all! Check out this recent ACS paper by Sarott et al., "Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry." The authors note "Recently, the attachment of cysteine-reactive chemical groups to pre-existing small molecule inhibitors has been shown to drive specific target degradation. We demonstrate here that different cysteine-reactive groups can specify target degradation via distinct ubiquitin ligases. . . finding that nearly identical compounds can engage multiple ubiquitination pathways suggests that targeting cellular pathways that search for and eliminate chemically reactive proteins is a feasible avenue for converting existing small molecule drugs into protein degrader molecules." Compelling work to advance protein degrader research! #drugdiscovery #drugdevelopment #protac #smallmolecules #scientificresearch #therapeutics

When selecting a biochemistry analyzer, understanding the price significance is crucial; it enables laboratories to balance financial constraints with the necessity for accurate and efficient testing. Check: https://lnkd.in/d_hsd7yx #BiochemistryAnalyzer #BiochemistryAnalyzers #Biochemistry #BloodTest #PathologyTest #PathologyLabTest #LabTest #Labtesting #BloodTesting #PathologyLab #Lab #drlogy #drlogyplus #BloodAnalyzer #PathologyLabMachine #LabMachines #LabEquipment #PathologyLabEquipment #laboratory #doctors #doctor #diagnostics #diagnostic #diagnosticservices #pathologylaboratory #laboratory

➤HPLC stands for "High-performance liquid chromatography"(sometimes referred to as High-pressure liquid chromatography). ➤High performance liquid chromatography is a powerful tool in analysis, it yields high performance and high speed compared to traditional columns chromatography because of the forcibly pumped mobile phase. ➤ It is used in biochemistry and analytical chemistry to identify, quantify and purify the individual components of a mixture.

If you missed our earlier post today we are excited to introduce the revolutionary PS-30 pilot scale peptide synthesizer. 🎉 Fast-Flow peptide synthesis combines the benefits of continuous flow with the robustness of Fmoc/tBu solid-phase peptide synthesis offering peptide chemists: ☑️ Synthesis scale 2.0 mmol to 30.0 mmol ☑️ Typical reaction time for a 30-mer peptide at 20 mmol scale is 16 hours ☑️ Fmoc solid phase peptide chemistry with DIC and oxyma activation ☑️ Continuous in-line analytics including resin solvation data and UV absorption data ☑️ State-of-the-art peptide synthesis software including sequence generator with automated addition of side chain(s) and real time analysis of synthesis quality ☑️ Minimises solvent and reagent usage. Solvent usage typically less than 70 ml per mmol / cycle even when using PEG resin Want to find out more? Click here https://bit.ly/3vF3D71 #FlowChemistry #PeptideChemists #ProductLaunch #PeptideTherapeutics