📢Event Recap: Peptide Synthesis Lunch and Learn at Stanford University📢 We are thrilled to share about our recent Peptide Synthesis Lunch and Learn event hosted at Stanford University! 🌲 🌟 🔬 Event Highlights: - Multiple labs from Stanford University Department of Chemistry and Stanford University School of Medicine were represented, fostering a dynamic exchange of ideas and collaboration. - Attendees had the opportunity to receive personalized peptide synthesis consultation from our co-founder, Dario Slavazza, who has over 30 years of peptide synthesis experience in R&D and cGMP environments. - Wesley Greiner shared some of the newest developments in research scale synthesis methodologies and advancements in green chemistry. - Engaging discussions on how the SPPS process differs once research is scaled up to gram and kilogram batches for process development and manufacturing. This event was a fantastic platform for knowledge sharing and networking, enhancing our collective understanding of peptide synthesis. A big thank you to all the attendees for making this event memorable and productive! Stay tuned for more such events as we continue to explore and innovate in the field of peptide chemistry! 🧬 If you are interested in having CSBio Instrumentation host a lunch and learn at your institution, don't hesitate to reach out! #StanfordUniversity #PeptideSynthesis #GreenChemistry #ResearchInnovation #Collaboration #ChemistryCommunity #MedicalResearch #ScienceEvents #SPPS #APS
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🔬 New Paper on the Importance of Chemical Libraries in advancing Drug Discovery 🔬 The quality of a chemical library significantly impacts drug discovery success. The paper titled "MBC and ECBL libraries: outstanding tools for drug discovery" has been published with the collaborative efforts of scientists Ana Martinez and Carmen Gil from the EU-OPENSCREEN medicinal chemistry partner site Centro Nacional de Biotecnología (CNB-CSIC) in Spain. Results of this analysis remark the high quality in terms of structural diversity and drug-like properties of the Medicinal and Biological Chemistry (MBC) and the EU-OPENSCREEN European Chemical Biology library (ECBL), making them great reservoirs of hits for drug discovery. 👉Learn more on our EU-OPENSCREEN chemical libraries here: https://lnkd.in/e2xgSbYN 🔗Check out the paper available on Frontiers in Pharmacology: https://lnkd.in/eFDJrNhx #drugdiscovery #chemistry #sciencenews
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🔬 CMC Analytical Comparability: Methods & Strategies For Biologics 🔬 Join us for an exclusive online live stream event featuring Prof. Dr. Johannes Buchner, a renowned expert in protein science! 🧪🧬 🌍 Date: 23 - 24 January 2024 📍 Location: Vienna, Austria | Online Live Stream 📚 About the Speaker: After attaining his PhD in biochemistry in 1991, Prof. Dr. Johannes Buchner worked at the National Institute of Health in Bethesda, USA. With an illustrious career, he has been holding a chair at the department of chemistry at the Technische Universität München since 1998. As a former dean of the department, he has extensive expertise in protein folding, stability, and cellular protein folding machinery. 🧪 🎓 Learn from the best: During this session, Prof. Dr. Buchner will delve into the fascinating world of CMC Analytical Comparability for Biologics. Discover the latest methods and strategies employed in the field, and gain valuable insights into the cutting-edge research conducted by one of the industry's leading experts! 🌟 💡 Don't miss out on this opportunity to expand your knowledge and network with like-minded professionals. Register now for the online live stream event and be part of this exciting learning experience! 🔗 Register here: https://lnkd.in/dXVZJW2i 👥 Tag someone who would be interested in this event and let's spread the word about this incredible opportunity! 📢 #CMCAnalyticalComparability #BiologicsResearch #ProteinScience #OnlineEvent #KnowledgeSharing #ProfessionalDevelopment
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Hello connections! I'm excited to announce that my 1st research article has been published online. 🎉📚 I am thrilled to share that the title of my 1st research article is "Identification of terpenoids as dihydropteroate synthase and dihydrofolate reductase inhibitors through structure-based virtual screening and molecular dynamic simulations." This significant milestone has been achieved with the publication of my research article in the prestigious Journal of Biomolecular Structure and Dynamics, which has an impressive impact factor of 5.235. 📝🔬 I am immensely proud of this accomplishment, and it serves as a strong motivation for me to continue pursuing my academic goals. 😊✌️ I owe a big thank you to my supervisor, Dr. Vikas Jaitak , and my co-authors: Amit Kumar, Kailash Jangid, and Dr. Vinod Kumar. Their support and contribution were instrumental in this achievement. For those interested in diving deeper into the details of the article, you can access it directly through the following link: https://lnkd.in/dRrvCDJz #ResearchArticle #Publication #research #ScientificAchievement #CUPB
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If you are attending Drug Discovery Chemistry in San Diego, drop by poster P031 to find out about Domainex's Direct-to-Biology platform, and how it can accelerate your project by utilizing high throughput synthesis, assay biology and ADME. #DrugDiscoveryChemistry #MedicinalChemistry #DirectToBiology #HighThroughput #AccelerateResearch
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Here is a summary of all #Chemspace news and highlights for June, in case you missed it: News & Collaborations: 1. Olena Strapak took part in the 38th ACS National Medicinal Chemistry Symposium! 2. A new Chemspace co-authored article is out! DOI:10.1126/science.adn6354 3. Special offer - Get a CCK-8 kit from TargetMol for just 1 USD/EUR. 4. Hot offer - free Antibody Samples from ProSci! Weekend article and corresponding service: Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency NEW Library Sets & Updates: Our General Pre-Plated Library is updated! #Meet_Chemspace_team: Meet our Account Manager - Olena Liutikova! Building Block and Screening Compound Sets: Building Blocks for Analogs of Seltorexant Meet a new post in the “Biologics for Research” series: Spleen tyrosine kinase (Syk) #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures
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🔬 CMC Analytical Comparability: Methods & Strategies For Biologics 🔬 Join us for an exclusive online live stream event featuring Prof. Dr. Johannes Buchner, a renowned expert in protein science! 🧪🧬 🌍 Date: 23 - 24 January 2024 📍 Location: Vienna, Austria | Online Live Stream 📚 About the Speaker: After attaining his PhD in biochemistry in 1991, Prof. Dr. Johannes Buchner worked at the National Institute of Health in Bethesda, USA. With an illustrious career, he has been holding a chair at the department of chemistry at the Technische Universität München since 1998. As a former dean of the department, he has extensive expertise in protein folding, stability, and cellular protein folding machinery. 🧪 🎓 Learn from the best: During this session, Prof. Dr. Buchner will delve into the fascinating world of CMC Analytical Comparability for Biologics. Discover the latest methods and strategies employed in the field, and gain valuable insights into the cutting-edge research conducted by one of the industry's leading experts! 🌟 💡 Don't miss out on this opportunity to expand your knowledge and network with like-minded professionals. Register now for the online live stream event and be part of this exciting learning experience! 🔗 Register here: https://lnkd.in/deJG9iPP 👥 Tag someone who would be interested in this event and let's spread the word about this incredible opportunity! 📢 #CMCAnalyticalComparability #BiologicsResearch #ProteinScience #OnlineEvent #KnowledgeSharing #ProfessionalDevelopment
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Interested in Synthesis of Sugar-Derived Heterocycles via Multicomponent Reactions, then read this detail review highlighting the growing utility of multicomponent reactions (MCRs) for the synthesis of diverse sugar-derived heterocyclic compounds. Divya Mathur and co authors provide an in-depth look at how sugars can be leveraged in a range of MCR methodologies. Key MCR approaches covered include the Passerini, Ugi, Petasis, Prins-Ritter, Mannich, and Hantzsch reactions, among others. The review showcases how the combination of sugars with diverse reactants can generate extensive libraries of glycoconjugate structures with potential biomedical applications. This work underscores the power of MCRs as efficient tools for diversity-oriented synthesis, harnessing the unique properties of sugars. The review is a must-read for synthetic and medicinal chemists interested in innovative approaches to accessing complex heterocyclic scaffolds. #ChemistryResearch #OrganicChemistry #SynthesisChemistry #Multicomponent_Reactions #SugarChemistry #HeterocyclicCompounds #DiversityOrientedSynthesis #DrugDiscovery SYNTHESIS Journal
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On this day in science Dorothy Hodgkin was born. Hodgkin is one of the most famous female chemists, and is known for her investigations into the structure of natural products using x-ray analysis. She was awarded the Nobel Prize in Chemistry in 1964 for these contributions. #chemistry #science #nobelprize #xray #biopharmaceuticals #pharmaindustry #sciencecommunication #scienceandtechnology #science #stem #womeninbusiness #womeninmedicine #womenempowerment #womeninscience #researchanddevelopment #medicalsciences #infographic via Compound Interest | Chemistry infographics
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Absolutely! Here's a more informative LinkedIn post about bioanalytical science: 🔬 Exploring the World of Bioanalytical Science! 🌐 In today's fast-paced world of scientific advancements, bioanalytical science stands as a cornerstone in our pursuit of understanding life's intricate mechanisms. 🧬 Whether it's quantifying biomolecules, studying cellular pathways, or unraveling the mysteries of disease, bioanalytical techniques provide us with invaluable tools to delve deeper into the realms of biology and medicine. 🔍 Chromatography, mass spectrometry, immunoassays, and spectroscopy are just a few examples of the powerful methods that fall under the bioanalytical umbrella. These techniques empower researchers to measure molecules with precision, detect subtle changes in biological systems, and contribute to the development of new diagnostics and therapeutics. 💡 One of the most exciting aspects of bioanalytical science is its constant evolution. As technologies improve, our ability to explore the microscopic world expands exponentially. We witness the fusion of biology, chemistry, and engineering, resulting in innovative solutions that were once considered science fiction. 🌱 From monitoring the effectiveness of drug treatments to detecting environmental pollutants, bioanalytical science plays a vital role in various fields, making a tangible impact on human health and our environment. It's a reminder that the pursuit of knowledge not only satisfies our curiosity but also leads to real-world benefits. So, here's to the scientists, researchers, and innovators who continue to push the boundaries of bioanalytical science. Your dedication to unraveling life's complexities inspires us all to strive for a better understanding of the world around us. Let's keep the scientific flame burning bright! 🔥🔬 #BioanalyticalScience #ScientificAdvancements #InnovationInTheLab
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International Sales Director Experience in Chromatography; Sales Strategist and Marketing Leader in the Life Sciences
#Therapeutics are an ever-evolving landscape of modalities which range in complexity but can be grouped into two broad categories: small molecules (chemically synthesized) and large molecules (#biologics). Small molecule therapeutics have historically dominated the marketplace and currently account for roughly 75% of all #pharmaceutical #drugs. The first therapeutic classified as a large molecule biologic (aka molecular elephant) to be approved by the #FDA was recombinant human insulin in 1982. The first FDA approval of a large molecule #antibody therapeutic, the murine antibody Muromonab-CD3 (OKT3), quickly followed in 1986. Since then, large molecules have become increasingly prevalent in drug development pipelines with more recent successes including many products with worldwide recognition such as the top-selling drug #Humira which is an antibody-based therapeutic for treatment of rheumatoid arthritis. Examples of large molecule therapeutics are: #Monoclonal antibodies Bispecific #antibodies #Antibody-drug conjugates (ADCs) #Recombinant enzymes #Polypeptides Adoptive cell therapies (ex. Chimeric Antigen Receptor or CAR T cells) Viral vector gene therapies (ex. Adeno-associated Virus or AAV) Non-viral vector gene therapies (ex. Lipid Nanopartical or LNP) Recombinant cytokines and growth factors. LC/MS has the ability to monitor multiple signature peptides throughout the protein structure which allows multiplexing during analysis for differentiation between the drug and its metabolites or between #protein isoforms, distinctions which can’t always be made with a traditional LBA or immunoassay. LC/MS is highly selective which aids in the assay performance when a therapeutic is homologous to endogenous protein(s). It also has a large dynamic range (4 orders) and can usually be implemented much faster than traditional LBA methods.
"Electrospray Wings for Molecular Elephants" On this day in science John B. Fenn was born. Fenn who shared the Nobel Prize for Chemistry in 2002 for developing techniques to identify and analyse proteins and other large biological molecules. When electrically charged molecules—ions—are accelerated by an electrical field, their speed depends on the ion’s charge and weight. By measuring the time, it takes for the ions to pass a certain distance, the incidence of different molecules in a test can be determined. It was impossible, however, to use this technique on large molecules. John Fenn et al. demonstrated the use of Electrospray ionisation (ESI) for the ‘soft ionization’ of biologically important ‘molecular elephants’, allowing high molecular weight biopolymers (i.e., proteins) to be analysed by mass spectrometry. In 1988 Fenn's group demonstrate that it was possible to transfer large molecules, such as proteins, as ions into the gas phase without breaking them apart. #chemistry #electrical #massspectrometry #massspec #biopharmaceuticals #biopharma #chemistry #biochemistry #bioanalysis #lcms #lcmsms #electrospray #scienceandtechnology #sciencecommunication #scienceeducation #proteins #analyticalchemistry #analytics #pharma
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🌞Peptides(DS)-Head Innovations,Automation🌞 🤷 Ex-Peptides Head(API) @ Dr.Reddys 🤦 ✅ Peptides API-Commerical Scale Mentor ⁉️ 💯 The Perspective Perception Guy 🧘 Reborn Versatile Artist
1moDon't miss it! Who can have the opportunity