Epoch Biodesign’s Post

“Purely ligand-based affinity prediction is challenging, with the presence of macrocycles compounding the complexity. We are excited to show how machine learning can build physically meaningful models for lead optimisation and how Optibrium’s QuanSA method, using an active learning strategy, can be applied to real-world molecular design.” Congratulations to Ann Cleves Jain, sharing her excitement above, and all the researchers involved in our new Open Access publication, now out in the Journal of Computer-Aided Molecular Design. They demonstrate the application of QuanSA for accelerated lead optimisation. Using an active learning approach, QuanSA enabled the successful, efficient identification of a mimic of a macrocyclic natural product. With QuanSA, far fewer synthetic steps were required, showing its potential to dramatically reduce costs and increase efficiency in macrocycle discovery projects. Learn more in our press release: https://lnkd.in/eRwz347c Or by reading the full paper: https://lnkd.in/eimkbspS #Macrocycles #CropProtection #3DDesign #ActiveLearning #MolecularDesign #OpenAccess

Read our latest blog post: A Closer Look at the Technology Behind Colony Picking Robots. Colony picking can be used in drug discovery, synthetic biology (syn-bio), picking for yeast; fungi; bacterial colony picking, and protein expression and purification. Automated colony pickers with robust software can process up to 2,500 colonies per hour, which is an incredible speed. Read more here: https://lnkd.in/eMPuUUjd #colonypicking #labautomation #synthetic biology #proteinexpression #software

CRISPR-Cas9 represents a watershed moment in the history of science and technology. Its potential to transform medicine, agriculture, and other fields is vast, but it also raises profound ethical questions. As we navigate this new era of genetic engineering, it is imperative to prioritize responsible innovation, ensuring that the benefits of this powerful technology are realized while mitigating the risks and addressing the ethical concerns. https://lnkd.in/ghf98dHK

Protein folding is one of the biggest, most compute-intensive challenges in biology, if not science itself. It's also a perfect problem to showcase the potential of the Bittensor ecosystem. Find out why in our latest Substack article: https://lnkd.in/eUB2ef7v #ProteinFolding #Bittensor #AlphaFold

Helping a company share the results their products yielded is central to GenoWrite's ethos. But just as important to me is the reproducibility of the data. Which is why I was delighted to see reproducibility efforts like this one emerging in ecology and evolution. There, they showed how a scientist's analytical approach can produce vastly different statistical conclusions. Works like this make me wonder how we too can assure reproducibility in clinical data for therapeutics and scientific data for biotech's many technological offerings. #reproducibility #biotech #sciencewriting #data

Read our latest issue of Wiley Analytical Science Magazine with the focus topic "instrument intelligence". #gitlabor, #AI, #InstrumentIntelligence, #TechRevolution, #InnovationJourney, #sustainability

Latest issue of Wiley Analytical Science magazine in case you missed it. Articles on AI, PFAs and other hot topics!

Genomics leader PacBio is a pioneer in long-read DNA sequencing, empowering scientists to better understand genomes for research ranging from healthcare to agriculture. However, generating extreme amounts of data from developing and manufacturing PacBio's highly accurate sequencers like the Revio and Sequel IIe Systems presents massive data challenges. Watch Director of IT & HPC, Adam Knight, discuss 'Why VAST' below 👇

It's not just "Hype" listen to how our customers are describing the VAST Data Platform and how it is solving challenging problems, improving performance and enabling their scientists to get their answers faster.. An improvement of 8x from their previous vendor.. Connect with myself or your local VAST team for more information! VAST Data

The Best Benchtop pH Meter: How to Choose the Right One for You... - How Exactly Do pH Meters Work? - Types of Digital pH Meters - Features to Consider for the Best Benchtop pH Meter - What Is the Best Benchtop pH Meter for Your Lab? Find out by reading our latest blog: https://lnkd.in/ezWWgXHa Hudson Robotics, Inc. offers multiple benchtop pH meters and add- ons for practical and specialised uses to help simplify your workload. To find out which is the best benchtop pH meter for your lab, speak to Verulam Scientific Ltd, the UK representative for Hudson Robotics - enquiries@verulamscientific.com 01234 381000. #VerulamScientific #Automation #Innovation #SamplePreparation #LiquidHandling #CustomisedSolutions #SyntheticBiology #HudsonRobotics #AutomatedLaboratoryEquipment #LifeScienceResearch #DrugDiscovery #ClinicalResearch #PharmaceuticalDevelopment #Screening #Proteomics #Genomics