MDPI’s Post

An interesting interplay between #green_tea #polyphenols & #Akkermanica & #obesity: NOTES: - addition of Tea polyphenols increased Akkermansia abundance in HF mice, which is consistent with previous research indicating that TP, #Cranberry, #chlorogenic acid, and #Grape also increase the colonization of #Akkermansia in the gut. - TP > increae in small intestinal goblet cells in TP-treated mice, which secrete mucins, a food source for Akkermansia development. - Polyphenols increase intestinal mucus secretion which is the food source of Akkermansia. - tea polyphenols (TP) significantly decreases the #Firmicutes / #Bacteroidetes ratio. - Suppression of Firmicutes by tea polyphenols and their metabolites favors Bacteroidetes in the gut of mice, indicating that tea polyphenols has a modulatory effect on the composition of the intestinal microbiota. - addition of Tea polyphenols increased Akkermansia abundance in HF mice, which is consistent with previous research indicating that TP, #Cranberry, chlorogenic acid, and #Grape also increase the colonization of #Akkermansia in the gut  - increase in small intestinal goblet cells in TP-treated mice, which secrete mucins, a food source for #Akkermansia development. - Polyphenols increase intestinal mucus secretion which is the food source of #Akkermansia. - tea polyphenols (TP) significantly decreases the #Firmicutes/#Bacteroidetes ratio. - Suppression of #Firmicutes by tea polyphenols and their metabolites favors #Bacteroidetes in the gut of mice, indicating that tea polyphenols has a modulatory effect on the composition of the intestinal microbiota. MyNotes: The health-promoting effects of consuming moderate and reasonable doses of green tea daily are well known, but it is very interesting that it may contribute to weight loss through #microbiome via mechanisms of akkermania and other healthy #microbiota and #metabolites that are not yet fully understood

Here we are! Day number 2 of the International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health - IPC2024! Yesterday Gustav Lindved delivered a great overview on the importance of looking into #clonal level resolution when planning #probiotic #clinicalstudies to understand the #engraftment status as well as the importance of the #phage profiling that can give us an additional perspective of the diversity changes upon the probiotic, #FMT or #LBP intervention. Clinical Microbiomics CosmosID DNASense

The time has come: the ����𝟲𝘁𝗵 𝗘𝗦𝗣𝗚𝗛𝗔𝗡 𝗔𝗻𝗻𝘂𝗮𝗹 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 𝗶𝗻 𝗠𝗶𝗹𝗮𝗻, 𝗜𝘁𝗮𝗹𝘆 (𝟭𝟱-𝟭𝟴 𝗠𝗮𝘆) is just around the corner! 📅 ⏳ Have you already heard about the 𝗴𝘂𝘁-𝗹𝘂𝗻𝗴 𝗮𝘅𝗶𝘀? New data show that HiPP ORGANIC COMBIOTIC® strengthens the gut-lung axis. The infant formula contains the unique combination of L. fermentum CECT5716, a probiotic bacterial strain originally obtained from breast milk*, and the prebiotic galacto-oligosaccharides (GOS) which together support an intestinal microbiota similar to that of breastfed infants. 👶 🍼 Bacterial metabolic products, including short-chain fatty acids (e.g. acetate and butyrate), are released into the bloodstream, thus allowing them to reach other parts of the body. Their immunomodulatory effects also mean they can have an influence on lung homeostasis, in a relationship now known as the gut-lung axis. *Breast milk contains a variety of natural cultures which can vary individually. Curious to know more? 👉 Visit us at booth no. 3 at the exhibition hall! We are happy to meet you in Milan as of 15 May! 🤗 For those who can’t wait: find out more about the clinically relevant data and check out our HCP website: https://lnkd.in/dJjZJ6Cw FOR HEALTH CARE PROFESSIONALS ONLY 👩⚕️ 👨⚕️ #HiPP #infantformula #combiotic #gutlungaxis #ESPGHAN2024

Role of mitochondria in dietary fat processing The researchers studied the function of mitochondria – organelles acting as powerhouses of the cell – in enterocytes, cells that line the intestine and specialize in the absorption and transport of nutrients from digested food. They found that disruption of mitochondrial function in the intestines of mice caused abnormal accumulation of dietary fat in enterocytes and impaired delivery of lipids to the peripheral organs. A key finding of the study was that, when mitochondria did not function properly, enterocytes showed impaired packaging and transport of lipids in the form of chylomicrons. Chylomicrons are crucial carriers of dietary fats, and their proper formation and transport are essential for the absorption of nutrients. #ScienceMission #sciencenewshighlights https://lnkd.in/gWqcjcXQ

A recent RCT aimed to investigate the effects of high-dose prebiotic fibre on food decision-making in overweight young adults. They found that after 14 days of prebiotic intake, participants showed reduced brain activation in response to high-calorie food cues. Additionally, there were significant shifts in the gut microbiota, with an increase in SCFA-producing Bifidobacteriaceae, and changes in predicted functional signaling pathways. The study suggests a potential link between prebiotic intake, gut microbiota changes, and alterations in reward-related brain activity during food decision-making. See full study: https://lnkd.in/edfzdpKw #nutritionresearch #prebiotics #guthealth #brainfunction #microbiome #foodchoices #healthstudy #healthyeating #sciencebehindfood #mindfuleating #dietaryfibre #healtyhabits #weightmanagement #researchfindings #bodyandmind #healthylifestyle

NUTRACEUTICALS 🌿💊 FOR PERSISTENT TICK-BORNE DISEASE MANAGEMENT The aim of this recently published study was to provide an evidence-based update of the literature on the use of bioactive phytochemicals, nutraceuticals, and micronutrients in the management of persistent cases of Borrelia burgdorferi infection (Lyme disease), Babesia and Bartonella species 🪲 👩🔬 👌 From Alchornea cordifolia to Uncaria tomentosa (Cat's claw) the paper discusses the agents that studies have found to be most effective 🎯 If you struggle to read (especially scientific papers!), scroll down to the table "Appendix A. Summary of Clinical Impact" 👍 Read the paper 🧐 https://bit.ly/3ODDCfy #lyme #lymedisease #tickbornediseases #lymescience

Turmeric powder counteracts Oxidative Stress & reduces Aflatoxin B1 (AFB1) level in Broiler Chickens

today's #cyclodextrin: is a bit old, but gold. We all know that CDs have been around in #nutraceuticals and #vitamin products for a while. And vitamin D is an ideal guest for encapsulation, also needs the support badly. In this paper, Francesco Trotta's team shows how to maximize the biological effects of vitamin D through its complexation within cyclodextrin nanosponge and how it affects two different gut–brain axes (healthy gut/degenerative brain and inflammatory bowel syndrome gut/degenerative brain axis). At the gut level, VitD3-NS mitigated liposaccharide-induced damage (100 ng/mL; for 48 h), restoring viability, integrity, and activity of tight junctions and reducing ROS production, lipid peroxidation, and cytokines levels. Following intestinal transit, VitD3-NS improved the neurodegenerative condition in the healthy axis and the IBS model, suggesting the ability of VitD3-NS to preserve efficacy and beneficial effects even in IBS conditions. In conclusion, this study demonstrates the ability of this novel form of VitD3, named VitD3-NS, to act on the gut–brain axis in healthy and damaged conditions, emphasizing enhanced biological activity through VitD3 complexation, as such complexation increases the beneficial effect of vitamin D3 in both the gut and brain by about 50%.

In our latest research, we assessed the anti-constipation property of polyphenol-rich extract of Digitaria exilis grains (PREDEG) in rifaximin-induced constipated rat. Our data present polyphenol-rich extract of D. exilis grains as a potent anti-constipation agent and may act probably by lowering gastrointestinal dysmotility. https://lnkd.in/dMrCm5Hs

Q: What are the 4 main types of Polyphenols? A: Flavonoids, lignans, stilbenes and phenolic acids. Dr Brad Leech, a PhD qualified Clinical Nutritionist has a special interest in chronic autoimmune conditions and complex gastrointestinal disorders. In his presentation, Dr Brad will delve into the dynamic interplay between dietary and supplemental polyphenols and their clinical impact on the gut microbiome and gastrointestinal health, shedding light on their potential therapeutic applications. Dr Brad will also examine how polyphenols influence the gut ecosystem and modulate intestinal barrier function, with a focus on their anti-inflammatory, antioxidant, antimicrobial and prebiotic actions. To learn more about Dr Brad’s presentation or to book your ticket: https://lnkd.in/gzs_YcG9 Early Bird ticket sales for the 9th Annual NIIM Symposium have been extended until midnight on 15th June! Be quick to secure your spot! Did you know that morning tea, lunch and afternoon tea is included in your ticket price?! *Note: The 9th Annual NIIM Symposium is strictly a healthcare practitioner-only event* #Polyphenols #GutHealth #IntegrativeNutrition #IntegrativeMedicine #GutMicrobiome #HealthEducation #ClinicalNutrition