MDPI’s Post

Summary: Dr. Tanya Dorff of City of Hope discusses two significant studies on prostate cancer immunotherapy presented at the ASCO annual meeting. The first study focused on a bispecific T-cell engager, tarlatamab, showing lower response rates and higher cytokine release syndrome, limiting its therapeutic potential. The second study, NEPTUNES, utilized an immune selection biomarker with ipilimumab-nivolumab, demonstrating improved response rates and manageable toxicity in mCRPC patients. These findings suggest promising advancements in immunotherapy for prostate cancer treatment. Hashtags: #ProstateCancer #Immunotherapy #ASCO2024 #Biohacking #HealthTips Read more here: https://lnkd.in/e4VwaAkT BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.

Journal of Cancer Therapy and Research  Unlocking Insights: Understanding Chemotherapy Efficacy in Bladder Cancer A recent study sheds light on why one particular type of chemotherapy stands out in combating this challenging disease. Research findings, as reported in Economic Times Health, underscore the significance of molecular mechanisms underlying chemotherapy response. Understanding why certain treatments excel can pave the way for more personalized and effective interventions, ultimately improving patient outcomes. This groundbreaking research not only expands our knowledge but also offers hope for advancements in bladder cancer care. hashtag Submit your work at: cancer@genesispub.org For any queries whatsapp at: +1 (438) 699-5365 #BladderCancer #Chemotherapy #MedicalResearch #HealthcareInnovation

NAD+ repletion with niacin counteracts cancer cachexia Muscle wasting syndrome called cachexia linked to comorbidity in cancer patients. Mitochondrial metabolism aberrations from nicotinamide adenine dinucleotide (NAD+ ) loss leads to tissue wasting. The researchers confirm in this study the depletion of NAD+ and downregulation of Nrk2, an NAD+ biosynthetic enzyme, are common features of severe cachexia. NAD+ repletion therapy with NAD+ precursor, vitamin B3 niacin in cachectic mice, efficiently corrects tissue NAD+ levels, improves mitochondrial metabolism and ameliorates cancer- and chemotherapy-induced cachexia. The authors show that muscleNRK2 is downregulated in cancer patients, who show metabolic abnormalities underscoring the significance of NAD+ in the pathophysiology of human cancer cachexia. #sciencenewshighlights #ScienceMission https://lnkd.in/gipynYzn

Summary: The article highlights the promising developments in targeted therapy and immunotherapy for endometrial cancer. Molecular tests can now identify specific molecular groups within endometrial cancers, leading to more precise prognostic counseling for patients. New therapies like trastuzumab deruxtecan and checkpoint inhibitors show significant benefits in treating advanced endometrial cancer, providing hope for improved outcomes in this disease. #EndometrialCancer #Immunotherapy #TargetedTherapy #PrecisionMedicine #PARPInhibitors Read more here: https://lnkd.in/evt5mGiA BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.

A deadly form of #ChildrensBrainCancer, #Immune to #Chemotherapy, is the target of new research looking at the #Epigenome and #ImmunoTherapies for answers. 🧠 #Paediatric high-grade #Glioma (pHGG) is the leading cause of disease-related death in children. Thanks to funding from the Medical Research Future Fund (MRFF) Dr Claire Sun will lead a team, including Dr Pouya Faridi as well as researchers from Children's Cancer Institute and Children's Medical Research Institute. Their research will make full use of our #ChildhoodCancerModelAtlas (#CCMA), a collection of more than 300 childhood cancer cell lines. 🧫 Read more about this research: https://bit.ly/3OWgUyQ Victorian Paediatric Cancer Consortium

🔬 Over C™: Pioneering Methylation-based Multi-Cancer Early Detection (MCED) Technology with Global Recognition   OverC™ MCED is intended for early detection of multiple cancer types (esophageal, liver, lung, ovarian, and pancreatic cancers) in adults of either sex, aged 50-75 years old, at average risk for cancer.   🌍 Key Milestones:   · Received "Breakthrough Device Designation" by both the FDA and NMPA. · Clinical validation published in the Annals of Oncology. · Based on the ELSA-seq technology platform (MCDBT-1 model), achieving 98.9% specificity and 69.1% sensitivity across six major cancers, and will be further validated in prospective interventional studies among asymptomatic population. · Outstanding tissue origin tracing capabilities, with accuracy rates of 83.2% for primary and 91.7% for both primary and secondary organs.   📈 Clinical Impact:   In real-world simulations, ELSA-seq shifted 38.7%-46.4% of late-stage cancers to earlier stages, increasing 5-year survival rates by 33.1%-40.4%.   🌐 Learn more about OverC™: https://lnkd.in/gjGX3ZSa   #OverC #CancerScreening #EarlyDetection #BurningRock #Liquid Biopsy

C57BL/6 and BALB/c mice were utilized from Envigo ++++ to study how the tumor microenvironment changes in triple-negative breast cancers with different levels of MHC-I expression. The researchers also explored potential combination immunotherapy strategies to overcome resistance to immune checkpoint inhibitors. #Immunotherapy resistance is a significant challenge in breast cancer treatment. This research highlights how varying MHC-I expression contributes to resistance against anti–PD-L1 therapy. It also identifies NKG2A on NK cells as a potential target to enhance treatment effectiveness. Read the full article article– https://lnkd.in/gS2p7fca To understand more on the C57BL/6 and BALB/c mice, visit:  https://lnkd.in/gDGwPZFe and https://lnkd.in/gVDGvQk2 GV Safety Assessment Platform (GVSAP), a subsidiary of GV Research Platform (GVRP), is a Hyderabad based pre-clinical CRO and an authorized breeder and distributor of Envigo ++++'s (an Inotiv company) research models & services in India. Reach us for more information: 📨: info@gvrp.in 🌐: www.gvrp.in #animalmodel #drugdiscovery #lifesciences #research #researchmodels #mousestrains #drugdevelopment #gvrp #envigo #cro #manuscript #invivostudies

The 𝐂𝐃2-𝐂𝐃58 𝐚𝐱𝐢𝐬 plays a crucial role in cancer immunotherapy by providing a valuable target to enhance anti-tumor immunity. Targeted therapies like 𝑺𝒊𝒑𝒍𝒊𝒛𝒖𝒎𝒂𝒃 and 𝑨𝒍𝒆𝒇𝒂𝒄𝒆𝒑𝒕 have shown effectiveness in managing conditions such as type 1 diabetes, transplant rejection, and psoriasis. Current clinical studies are concentrating on developing treatments that focus on CD2 and CD58 for various diseases, with a particular emphasis on cancer therapy. 𝐒𝐢𝐧𝐨 𝐁𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥's product line is helping researchers uncover the interactions between CD2 and CD58, making significant contributions to the progress of understanding and potential therapeutic approaches in this field. 𝐂𝐡𝐞𝐜𝐤 𝐭𝐡𝐞𝐦 𝐨𝐮𝐭 𝐚𝐭 www. sinobiological. com/category/ads/cd2-cd58-axis Sino Biological, Inc.: 𝑷𝒖𝒓𝒆 𝒂𝒏𝒅 𝒓𝒆𝒍𝒊𝒂𝒃𝒍𝒆 𝒓𝒆𝒄𝒐𝒎𝒃𝒊𝒏𝒂𝒏𝒕 𝒑𝒓𝒐𝒕𝒆𝒊𝒏𝒔 – 𝑭𝒓𝒐𝒎 𝒐𝒖𝒓 𝑬𝒙𝒑𝒆𝒓𝒕𝒔, 𝒕𝒐 𝒀𝒐𝒖! #CD2 #CD58 #Immunotherapy #TargetedTherapies #CancerTreatment

𝗕𝗿𝗼𝗰𝗰𝗼𝗹𝗶 & 𝗦𝘂𝗹𝗳𝗼𝗿𝗮𝗽𝗵𝗮𝗻𝗲 𝗳𝗼𝗿 𝗯𝗿𝗲𝗮𝘀𝘁 𝗖𝗮𝗻𝗰𝗲𝗿! A breast cancer cell study reaffirms that broccoli contains Sulforaphane which in combination with chemotherapy targets the crux of cancer: its cancer stem cells. Sulforaphane inhibits breast CSCs and downregulates the Wnt/beta-catenin self-renewal pathway. These findings support the use of Sulforaphane for the chemoprevention of breast cancer stem cells and warrant further clinical evaluation. Read more to discover scientific evidence of broccoli as a cancer-healing food. https://lnkd.in/epRNUu9E Follow addon.life for updates on Cancer Nutrition! . #cancerdiet #dietplan #personalizednutrition #mealplans #nutritionforcancer #healthyfood #fitnessdiet #clinicalnutrition #breastcancer