“Our immune systems, our synapses, even our placentas & embryos are all driven by viruses.” —Carrie Arnold #virus #health #biology
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📢 A Novel #MarineMammal #Coxiella burnetii—Genome Sequencing Identifies a New Genotype with Potential Virulence 👨🎓 by Brett Gardner et al. The obligate intracellular bacterial pathogen Coxiella burnetii has been identified in a few species of marine mammals, some of which are showing population declines. It has been hypothesized that C. burnetii in marine mammals is a distinct genotype that varies significantly from the typical terrestrial genotypes. It appears to lack an IS1111. Isolates originating from Australian marine animals have a distinctly non-Australian profile of multiple-locus variable-number tandem-repeat analysis (MLVA). Extracted Coxiella DNA of Australian fur seal placental origin was sequenced using the Novaseq platform. Illumina 150 bp paired-end reads were filtered and trimmed with Trimgalore. The microbial community present in the sequenced genome was evaluated with Kraken and Bracken software using the NCBI database. A phylogenetic analysis was performed using 1131 core genes. Core genes were identified using Panaroo and inputted into Iqtree to determine the maximum-likelihood tree. A second phylogenetic tree was created using Rickettsiella grylii and using seven housekeeping genes. Results were compared with the C. burnetii Nine Mile RSA439 virulent genome. This new Australian marine mammal isolate of Coxiella (PG457) appears to be a novel genotype that lacks IS1111 and has a distinct MLVA signature (ms26, ms27, ms28, ms30, and ms31). The presence of genes for multiple virulence factors appears to give this genotype sufficient pathogenicity for it to be considered a possible causative agent of abortion in Australian fur seals as well as a potential zoonotic risk. 🔗 Full article: https://lnkd.in/gVSYUxwn 👉 This article belongs to the Topical Collection: Updates on Rickettsia and Coxiella https://lnkd.in/gUjRVT8d
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Did you know that a newly discovered #coronavirus found in bats has the genetic traits to spread in humans? 👀 Watch the video to find out more and click the link below to read the full article! https://brnw.ch/21wC3oB #pathology #pathologylab #Pathologist
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All headgears of hoofed mammals come from a common ancestor: The headgear of ruminant hoofed mammals, including horns and antlers, evolved from a common ancestor, according to new genomic research. #Heagear #Horns #Antlers #GenomicResearch #Genetics #HoofedMammals #Ossicones #Evolution #EarthDotCom #EarthSnap #Earth
All headgears of hoofed mammals come from a common ancestor
earth.com
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Large-scale invasion of unicellular eukaryotic genomes by integrating DNA viruses Protists are a diverse collection of predominantly unicellular eukaryotic organisms that are not animals, plants, or fungi. They make up most of the eukaryotic tree of life, are major components of nearly all ecosystems and are critical for carbon and nutrient cycling. In this study, we found that large parts of protist genomes are viral in origin and that these viral integrations are comparable in scale to prophage integrations in bacterial genomes. Protist EVEs were distantly related to virophages, a group of viruses which parasitize on larger “giant viruses” that infect and kill their eukaryotic hosts. Many EVEs (Endogenous Viral Elements) appear to be functional viruses, which suggests that diverse arrays of these elements may be part of a host antivirus system. https://lnkd.in/dSNxdHEH #molecularbiology #biochemistry #virology #biology #biologyteacher
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Were you ever wondering how the changes after fertilization are coordinated, from an #oocyte to a totipotent #embryo? Our study published in EMBO Reports shows that: - CHK1 protects genome integrity by preventing premature mitosis in 2-cell mouse embryos, and thus - CHK1 ensures the long G2 phase associated with the major phase of genome activation, when - CHK1 restricts CDK1 activity and causes CDC25A degradation. These results offer new insight into embryonic development and could be useful for #fertilityclinic, as division timing is one of the assessed factors for embryo selection during #assistedreproduction. You can find the study here: https://lnkd.in/ecmd9_8i I would like to thank all my colleagues, including Tomáš Ďuríček, Michaela Vaškovičová, Diana Rayová, Chrysoula Zorzompokou and most importantly, Richard Schultz, Eva Hoffmann and David Drutovic! A big thanks goes also to our funding bodies: Charles University, Institute of Animal Physiology and Genetics, Academy of the Sciences of the Czech Republic, European Research Council (ERC), Københavns Universitet - University of Copenhagen and the Czech Science Foundation.
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Investigating the evolutionary landscape of lineage-specific accelerated regions (LinARs) across 49 primate species. Lineage-specific accelerated sequences underlying primate evolution https://lnkd.in/gJK-geeY
Lineage-specific accelerated sequences underlying primate evolution
science.org
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Managing Director at Incite Leadership | Executive Coach | Top Team Facilitator | ex McKinsey | ex Neuroscientist | ex Psychology Instructor
Here is a fun one, for those of us interested in the intersection of neuroscience and leadership. A bit of background: our thinking and our behavior is altered not only by our own DNA, but also by the various genetic makeups of the viruses, parasites and bacteria that get integrated into our systems. One of the most famous examples of this is Toxoplasma gondii, a parasite that can only sexually reproduce - aka, stay alive - by being inside the digestive system of a cat. Problem is, toxoplasma gondii can actually infect most mammals... but then it gets stuck. It can infect a rat, or a wolf, or a human, but then it can't reproduce. So what did this sneaky parasite do, when it found itself stuck in a rat instead of a cat? It changed the brains of the rat, so the rat was essentially sexually attracted to the smell of cats and simultaneously, was much less afraid of these felines. The result was very bad for the rats... as they pretty much began jumping into the jaws of their newly beloved predators. But great outcome for T. Gondii... as once the cat ate the rat, it also became the perfect host, allowing T. Gondii to replicate at will. New research has now come out on Toxoplasma gondii and wolves, who fare a bit better than the rats. Being infected as a wolf actually makes you 46x more likely to become the pack leader. (It also makes you 11x more likely to end up leaving the pack, than those who were not infected.) The mechanisms are similar to the ones in rats: increased preference for the smell of cat urine and decreased anxiousness / increased risk taking. But wolves tend to interact more with cougars than housecats, and when driven to increase their search for these felines, this behavior tends to result in the wolf finding new territory (now shared with a few cougars, but this doesn't seem to be so bad). Overall, a better outcome than the rat's death, even thought it is a final act worthy of a Greek tragedy. So the next time we are tempted to blame nature or nurture for our leadership abilities, perhaps we should ask what else could be influencing us. After all, about 50% of us humans are infected with Toxoplasma gondii already. It's more likely to explain our tolerance for the smell of cats than our leadership... but there are studies that indicate this parasite influences us in many of the same ways as rats and wolves, if to a somewhat lesser extent. https://lnkd.in/gUJ5TRpc
Something Strange Happens to Wolves Infected by Infamous Mind-Altering Parasite
sciencealert.com
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CEO, Cybernetician, EVES ENERGY / Finamatrix.NET / SkillsFuture Trainer / Biofuel / Biofood / Bioplastic / Biofabric / Art-Scientist / Geroscience / Satellite Data / Net Zero
The life cycle of the #immortal #jellyfish, scientifically known as **Turritopsis dohrnii**, is quite fascinating. This species is known for its ability to revert its cells to their earliest form and grow anew, effectively rendering it biologically immortal³. Here's a brief overview of its life cycle: 1. **Eggs and Sperm**: Like most jellyfish species, they have eggs and sperm which get released to be fertilized². 2. **Free-Swimming Larval Form**: From the fertilized eggs, you get a free-swimming larval form². 3. **Polyp Stage**: The larva moves about in the current until it finds a hard surface to establish itself. It then starts to mature and grow into a polyp². 4. **Medusa Stage**: The polyps then bud off and mature into young jellyfish, also known as medusae². The immortal jellyfish has a unique ability to reverse its life cycle. When the medusa of this species is physically damaged or experiences stresses such as #starvation, instead of dying, it shrinks in on itself, reabsorbing its tentacles and losing the ability to swim². It then settles on the seafloor as a blob-like cyst². Over the next 24-36 hours, this blob develops into a new polyp². This phenomenon has been likened to that of a butterfly which, instead of dying, would be able to transform back into a caterpillar and then metamorphose into an adult butterfly once again². The process behind the jellyfish's remarkable transformation is called **#transdifferentiation**². This process reprogrammes the #medusa's specialized cells to become specialized polyp cells, allowing the jellyfish to regrow themselves in an entirely different body plan to the free-swimming jellyfish they had recently been². They can then mature again from there as normal, producing new, genetically identical medusae². This life cycle reversal can be repeated, and in perfect conditions, it may be that these jellyfish would never die of old age².. Source: (1) Turritopsis dohrnii - Wikipedia. (2) Immortal jellyfish: the secret to cheating death. https://lnkd.in/g6cnNjAE (3) undefined. https://lnkd.in/gRrqmfeT. (4) ‘Immortal Jellyfish’ Could Spur Discoveries About Human Aging. https://lnkd.in/gC4zigCB. (5) News of the Day: Immortal Jellyfish | Ocean Today. https://lnkd.in/gK7yeVTh. (6) The 'Immortal Jellyfish' Can Age in Reverse And Possibly Live Forever. https://lnkd.in/gjQ9FxPi. (7) en.wikipedia.org. https://lnkd.in/ghp8DhGr.
Immortal jellyfish: the secret to cheating death
nhm.ac.uk
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Scientists at ETH Zurich have devised a technique for genetically modifying individual cells separately within animals. This innovation streamlines the research process, eliminating the need for numerous animal experiments. By applying this novel approach, the scientists have pinpointed genes linked to a severe, rare genetic disorder. #Biology #Genetics #Science #Zoology #Scitke
Genetic Alteration of Individual Animal Cells
https://scitke.com
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Early-onset glaucoma is a leading cause of blindness in children. Stay informed on the latest advancements in childhood #glaucoma at the ARVO-AAO on-demand joint symposium. Get a comprehensive review of genetics, ocular angle development, biologic interactions, animal models, and current treatments: https://bit.ly/45WlAKI #visionresearch #ophthalmology
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