Parse Biosciences’ Post

Though known for our high content capabilities, our expertise is much broader than that! To meet our clients’ needs, we are constantly adding new capabilities, with one of the latest additions being the FLIPR system from Molecular Devices. With this, we can provide you data from live, function-based assays in many in vitro systems, including: • Cardiotoxicity screens • Assessments of the activity of neurons and neurospheres • Evaluation of GPCR and ion-channel targets • Detection of changes in membrane potential Pictured here are the activity profiles of iCell cardiomyocytes (FUJIFILM Cellular Dynamics) treated with the beta blocker sotalol and the beta adrenergic-receptor agonist isoproterenol. Using the FLIPR, we captured time-resolved differences in the cells’ activities that resulted from compound treatment. Pairing this kind of information with high-content data gives you deeper understandings of your therapeutic candidates’ biological effects to accelerate your drug-development programs. Shoot us a message at https://hubs.ly/Q026kSyT0 to learn more! #FLIPR #DrugDiscovery

A good day to share the publication of the validation of FoundationOne Tracker, a therapy response ctDNA monitoring assay. https://lnkd.in/ecdQHDBQ

We think "functional QC" can be a key tool to enhance confidence in advanced in vitro disease models. But what is functional QC (fQC)? How could it be applied to iPSC technology? And why are we striving to incorporate fQC in our cell manufacturing? We discuss this in our latest thought piece, where we discuss the role of fQC in producing useful, functional cells that can fuel advanced in vitro models with enhanced translational power. Click here to learn more about it and download the thought piece: https://hubs.la/Q02l9bLs0 P.S., We're hosting our first webinar of the year on the 28th February (4pm GMT), entitled "QC, Functional QC & iPSCs: the importance in better human disease modeling". Click here to register: https://hubs.la/Q02l9gJ50 #iPSCs #ISO9001 #StemCells #functionalQC #DrugDiscovery

Take Circulating Tumour Cell (CTC) analysis to the next level with ANGLE’s Portrait® Flex assay service.   The Portrait Flex assay is used to identify and enumerate the captured CTCs and offers an additional open channel that can be used to detect your therapeutic target or biomarker of interest.   With the convenience and reassurance that analyses are tailored to your requirements and conducted by scientific experts at ANGLE’s GCP-compliant laboratory. Our Parsortix® system is used to capture CTCs based on their size and deformability, enabling the isolation and enrichment of live epithelial, mesenchymal and epithelial-to-mesenchymal transition CTCs and CTC clusters.   Click here to find out more: https://lnkd.in/e8A9q4mk #ANGLEplc #Parsortix #LiquidBiopsy #CTC   For Research Only. Not for Use in Diagnostic Procedures.

Reliable and robust sample analysis is essential throughout in vitro transcription (IVT) mRNA workflows. In this webinar, learn about the quality control (QC) steps that can be performed by the Fragment Analyzer and how they can improve the IVT process. Presented by: Whitney Pike, Dr. Leslie Friedmann, Prof. Harris Makatsoris Agilent Technologies #sampleanalysis #webinar #mRNA #IVT

We think "functional QC" can be a key tool to enhance confidence in advanced in vitro disease models. But what is functional QC (fQC)? How could it be applied to iPSC technology? And why are we striving to incorporate fQC in our cell manufacturing? We discuss this in our latest thought piece, where we discuss the role of fQC in producing useful, functional cells that can fuel advanced in vitro models with enhanced translational power. Click here to learn more about it and download the thought piece: https://hubs.la/Q02l99-W0 P.S., We're hosting our first webinar of the year on the 28th February (4pm GMT), entitled "QC, Functional QC & iPSCs: the importance in better human disease modeling". Click here to register: https://hubs.la/Q02l9hRb0 #iPSCs #ISO9001 #StemCells #functionalQC #DrugDiscovery

𝗔 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗖𝗮𝗿𝗱𝗶𝗼𝘁𝗼𝘅𝗶𝗰𝗶𝘁𝘆 𝗔𝘀𝘀𝗮𝘆 𝗳𝗼𝗿 𝗘𝘃𝗮𝗹𝘂𝗮𝘁𝗶𝗻𝗴 𝘁𝗵𝗲 𝗦𝗮𝗳𝗲𝘁𝘆 𝗼𝗳 𝗖𝗲𝗹𝗹 𝗧𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀 Explore our latest application note to learn about an innovative method for assessing on-target, off-tumor side effects of CAR T cells in vitro on Axion's next-generation Maestro Pro platform. #StemCells #Cardiotoxicity #CellTherapy #MaestroMEA #SafetyPharmacology

'Success backed by customer stories 💪 The WAVEsystem’s components have been put to the test. Through this customer story you’ll find out how the Creoptix WAVEsystem drives real-time kinetic and affinity analysis for faster and better characterization of candidates. The impact? * Hit screening campaigns cut from weeks to days * Faster hit-to-lead progression with superior resolution of off-rates above 1 s-1 * Six promising Sybody® binders to Spike RBD identified and rapidly characterized * Antibodies characterized directly from clinical blood plasma samples Dive into the details by downloading the customer story here 👉 https://bit.ly/3R7GIKu #MalvernPanalytical #CreoptixWAVEsystem #CustomerStory

There are certain limitations with current approaches and modalities to effectively inhibit challenging clinically validated targets. However, the emergence of new modalities like PROTAC offers promising solutions to these obstacles in the clinic. This review provides valuable insights into PROTAC development. https://lnkd.in/esCctFYc

Highlighted Product Citation (Clinical Trial)! "Results: We identified 27 proteomic candidates, miRNA and three microbial strains to be dysregulated in AD. CCL17, CCL13, CCL22, E-selectin and BDNF were differently regulated and significantly associated with treatment response. In contrast, neither the microbial composition nor the miRNA pattern was associated with treatment response upon dupilumab treatment." How'd they do it? Read the paper to find out! https://lnkd.in/eV3jcz3b RayBiotech Product: Quantibody Human Cytokine Array Q440 chip Proteome Screening Arrays: https://lnkd.in/eSN3PYQM