Tierra Biosciences’ Post

🔍 You need to precisely determine the #PEGylation levels (free protein, free PEG and PEG-protein conjugates) of a #protein? In this #ApplicationNote, you could see how PEGylated #Fab and #scFv samples were separated by #TSKgel #UPSW2000 and detected by RI, UV as well as #MALS with #LenS3 for composition analysis.  Link for download: https://lnkd.in/etYAhq45 Tosoh Bioscience - Separations & Purification #chromatographyexperts #UHPLC #SEC

🔍 You need to precisely determine the #PEGylation levels (free protein, free PEG and PEG-protein conjugates) of a #protein? In this #ApplicationNote, you could see how PEGylated #Fab and #scFv samples were separated by #TSKgel #UPSW2000 and detected by RI, UV as well as #MALS with #LenS3 for composition analysis. Link for download: https://lnkd.in/etYAhq45 Tosoh Bioscience - Separations & Purification #chromatographyexperts #UHPLC #SEC

🔍 Did You Know? The roots of affinity chromatography date back to 1968 when Spanish biochemist Pedro Cuatrecasas pioneered the technique for protein purification. 🧪 Fast forward to 2017, and TriAltus revolutionized the game with the patented CLīM system – an innovative affinity chromatography approach. It is known for simplifying ultra-high-quality recombinant protein production in a single chromatographic step.  #AffinityChromatography #ProteinPurification #TriAltusInnovation

Unlock the future of protein purification with 𝐂𝐲𝐭𝐢𝐯𝐚™ 𝐏𝐫𝐨𝐭𝐞𝐢𝐧 𝐒𝐞𝐥𝐞𝐜𝐭™ 𝐫𝐞𝐬𝐢𝐧!  Simplify your workflow with our innovative affinity chromatography resin, designed for purifying recombinant proteins using the self-cleaving Protein Select tag. Experience one-step purification and tag cleavage without proteases or elution reagents, delivering highly pure, native proteins. Available in multiple formats, this technology ensures no protein aggregation or loss of biological activity, making it perfect for various expression systems. 🔗 𝐑𝐞𝐪𝐮𝐞𝐬𝐭 𝐅𝐫𝐞𝐞 𝐄𝐱𝐩𝐞𝐫𝐭 𝐆𝐮𝐢𝐝𝐚𝐧𝐜𝐞: https://lnkd.in/gM_UGHSE #ProteinPurification #RecombinantProteins #AffinityChromatography #BiotechInnovation #LabEfficiency #Cytiva #ProteinSelect #Bioprocessing #BiotechResearch #Proteomics #LabAutomation #ProteinScience #ResearchTools #ScientificBreakthrough #ProteinTechnology

Kemp Proteins demonstrating high productivity/rapid cycle Protein A membranes in HTP approach to screening more potential therapies with: - comparable consumable costs - similar CQAs to resin - faster process times See the poster to learn more. #antibody #purification

Bioprocess impurities: devising and implementing comprehensive control strategies for bioprocess impurities can be challenging. Sources of bioprocess impurities range from cell substrates (e.g., host cell DNA, host cell proteins, etc.) – to impurities resulting from biomanufacturing processes such as cell culture (e.g., media components, antibiotics, inducers, etc.) and chromatography (e.g., resin leachates, solvents, buffer components, etc.). Neva’s team are ready to provide exactly the support you desire: from nimble in-house characterization testing, process development, etc. at Neva, to external on-site evaluation and support where you need it. Contact Neva at info@nevaanalytics.com for assistance. #nevaanalytics #impurities #bioprocessimpurities #inducers #antibiotics #antifoam #mediacompounds #buffercomponents #oxidizingchemicals #reducingchemicals #stabilizers #surfactants #βglucan #hostcellDNA #hostcellprotein #processreagents #processresiduals #excipients  

𝐁𝐢𝐜𝐲𝐜𝐥𝐨𝐚𝐥𝐤𝐚𝐧𝐞 𝐁𝐮𝐢𝐥𝐝𝐢𝐧𝐠 𝐁𝐥𝐨𝐜𝐤𝐬 𝐚𝐬 𝐁𝐞𝐧𝐳𝐞𝐧𝐞 𝐁𝐢𝐨𝐢𝐬𝐨𝐬𝐭𝐞𝐫𝐬 In recent years, there has been active research aimed at breaking the planarity of pharmacologically active molecules to improve their solubility and in vivo behavior. This approach involves replacing the benzene ring with bioisosteres. 𝐓𝐨 𝐋𝐞𝐚𝐫𝐧 𝐌𝐨𝐫𝐞: https://lnkd.in/gnEm8m3Q #drugresearch #pharmaceuticalresearch #organicchemicals #chemicalsynthesis #benzene #benzenering #researchchemicals #drugdiscovery #buildingblocks #laboratoryreagents #trustedchemicalpartner #TCIproduct

My colleague Aid is providing interesting insights on methanol-free processes with UNLOCK PICHIA at RPP11!

Biotin-PEG(3)-ATFB/Biotin-TEG-ATFBA/ Biotin-triethylenglycol-(p-azido-tetrafluorobenzamide) has been used as photo-cross linker (Lamda max = 258nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers. Biotin-triethylene glycol-(p-azido-tetrafluorobenzamide) is a versatile compound that combines the affinity of biotin for avidin, the flexibility and hydrophilicity of the TEG linker, and the reactivity of the azide group for selective bioconjugation through click chemistry. It is commonly used in applications such as protein labeling, immunoassays, and the construction of bioactive surfaces. #Biotin-#PEG(3)-#ATFB/ #Biotin-#TEG-#ATFBA/ #Biotin-#triethylenglycol-(#p-#azido-#tetrafluorobenzamide) #photo-#cross #linker #protein #labeling, #immunoassays https://lnkd.in/gWT-KkCB