Weill Cornell Medicine’s Post

A research study co-authored by Suneet Mittal, MD, FACC, FHRS, Chair of the Cardiovascular Service Line for Valley Health System, was recently published in the Journal of Cardiovascular Electrophysiology. The authors of the study presented results of the FROZEN AF trial, unveiling a novel 28mm cryoballoon system for treating paroxysmal atrial fibrillation (PAF). Conducted across 10 countries, this study demonstrates impressive results with 95.7% complete pulmonary vein isolation achievement and 79.9% freedom from documented atrial arrhythmia recurrence at the 12-month mark. This research underscores the safety and efficacy of this innovative cryoballoon, offering promising avenues for patients with drug-refractory or drug-intolerant PAF. To read the full study, please visit https://lnkd.in/eBMyVGr7. #CardiacResearch #CardiacPublication #Electrophysiology #MedicalResearch

Congratulations to the authors of this week's Publication Spotlight! Sadi Loai, Beiping Qiang, Michael Laflamme and Hai-Ling Margaret Cheng This study aimed to use blood-pool MRI to assess how the heart's microvascular system responds to changes in blood gas levels, specifically looking for differences between male and female subjects. The research involved healthy rats exposed to normoxia and hypercapnia while undergoing MRI scans and laser Doppler perfusion measurements. Results showed that female rats exhibited myocardial vasodilation during hypercapnia, while males did not show significant changes. Both sexes experienced vasoconstriction upon returning to normoxia. The study concluded that blood-pool MRI is effective in detecting these responses and highlighted sex-related differences in how the heart's microcirculation reacts to mild changes in blood gas levels, which could have implications for understanding cardiovascular function and dysfunction. The data was acquired on a MRS*DRYMAG 3T system at the University of Toronto. The article was published in Frontiers in Cardiovascular Medicine late last year. The publication is available at: https://lnkd.in/dcQjZZWQ #MRI #cardiology #preclinical

Join our satellite symposium at the TCT 2023 and discover the future of coronary physiology! We are happy to announce the third and last speaker, Dr. Olga Toleva, in our insightful symposium: 'Non-Invasive Physiological Approaches to Epicardial and Microvascular Disease in the Cath Lab'. In this presentation, Dr. Toleva will discuss rapid non-invasive assessment of the full coronary tree with QFR-IMR.”. 🔎 Explore the untapped potential of testing for CMD in INOCA, MINOCA, and Takotsubo patients 🙌 Discover the value of rapid, non-invasive CMD evaluation and its implications in these three indications 💡 Get ready to witness the groundbreaking first cases with QFR-IMR that are reshaping the landscape of coronary assessment 📅 Save the date: 25-10-23 - 09:30 - 10:45 AM in room 205, level 2 . . . #QFR #PhysiologyMadeSimple #CoronaryPhysiology

Exploring the Nuances of Left Atrial Pressure in Critical Care 🏥 A breakthrough review by Emma Maria Bowcock & Anthony Mclean uncovers the complexities of assessing left atrial pressure in critically ill patients. This insightful work highlights: 🔍 The need for a comprehensive understanding of left atrial physiology. 🩺 The integration of invasive and non-invasive methods in clinical practice. 🚑 Key insights for differentiating cardiac failure phenotypes in critical care. https://lnkd.in/gfH4tZSb 🌟 Earn 1.0 CME and deepen your understanding of cardiac assessments in critical care settings. #CriticalCare #Cardiology #MedicalEducation #CME #PhysicianInsights

https://lnkd.in/gpfj2XBH Article title: Can Irisin be a New Agent Responsible for the Development of Heart Attack and Cardiac Cachexia? Author(s): Suna Aydin* Journal: Journal of Cardiovascular Medicine and Cardiology Journal ISSN: 2455-2976 Editorial: Cardiac cachexia, a syndrome characterized by systemic destruction, nutritional impairment and weight loss [1], has a prevalence ranging between 8 and 42% around the world [2]. The syndrome was first described by the father of medicine, Hippocrates, as follows: “the flesh is consumed and becomes water; shoulders, clavicles, chest and thighs melt away. #CoronaryArteryDiseases #ValvularHeartDisease #Electrophysiology #CardiacElectrophysiology #Echocardiography #InterventionalCardiology #ClinicalCardiology #NuclearCardiology #AcuteCoronarySyndromes #ArrhythmiaEP #CVImaging #CVDPrevention #CardiacArrhythmias #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #CardiacPhysiology #CardiacRegeneration #CardiacRehabilitation #Cardiomyopathies #CardiovascularDrugs #CardiovascularTherapy #CardiovascularAnatomy #CongenitalHeartDefects 

💡 Application in the spotlight! In this study by Mazzocco and Murtaj et al. of the Università degli Studi di Milano-Bicocca and the Ospedale San Raffaele, 18F-FDG PET-CT was used to evaluate the metabolic connectivity between brain regions in rat models for neurodegeneration. Thanks to the high spatial resolution of the B-CUBE, the researchers were able to visualize and quantify regional brain metabolism and connectivity in cortical and subcortical regions in a non-invasive manner. 🔗 Link to the application can be found here: https://lnkd.in/evRmivZd #PreclinicalImaging #PET #CT

Excited to inform you that our article "Resting-state functional connectivity-based parcellation of the human dentate nucleus: new findings and clinical relevance" has been published online in Brain Structure and Function.  We highlight the importance of functional parcellation in refining our understanding of broad resting-state functional connectivity (RSFC) in both health and disease. First, we review work relevant to the functional topography of the dentate nuclei, including recent advances in functional parcellation. Next, we review RSFC studies using the dentate nuclei as seed regions of interest in neurological and psychiatric populations and discuss the potential benefits of applying functionally defined subdivisions. Finally, we discuss recent technological advances and underscore ultrahigh-field neuroimaging as a tool to potentiate functionally parcellated RSFC analyses in clinical populations. https://rdcu.be/dgNqh

Discovery of a New Part in the Brain Might Impact Alzheimer’s You might think we know about almost all the parts of the brain. While we probably do for most physical parts of the brain, we still need to learn about their functions. On functions, we are definitely still learning…a lot! So, surprisingly there’s a new part of the brain that was recently discovered. It’s called by the long name - subarachnoid lymphatic-like membrane. We’ll use the shortened name – SLYM (that’s so much easier!) SLYM is a very fragile membrane that encases the brain and the SLYM disintegrates when there is an autopsy. This means that none of the NCIS tv shows or real docs would have ever discovered it. The researchers were able to discover it by using the latest high-resolution microscopy. They have also begun to figure out what it does…which is the really interesting part. Since it encircles the brain, the SLYM membrane’s purpose seems to be to keep toxic fluids out of the brain! It’s designed to be part of the brain’s waste disposal system. It keeps newly made cerebrospinal fluid separate from the “dirty” fluid that contains the body’s waste products. The importance of this discovery is that the SLYM membrane may be a factor in a number of diseases including Alzheimer's disease, multiple sclerosis and central nervous system disease infections. One word of caution here and it’s that lumbar punctures and epidurals can damage the membrane. Would patients willingly get lumbar punctures and epidurals if they knew that this could damage the membrane? Or does more research need to be done to find a way to protect the SLYM and still get information that’s needed for treatment? (Reported WDDTY. September 2023) Here are a couple of quotes from Hippocrates that I just ran across that I found to be really interesting. “If you are not your own doctor, then you are a fool” That’s pretty strong and clear! “The greatest medicine of all is teaching people how not to need it.” “The natural healing from within each of us is the greatest force in getting well.” Great word of wisdom from Hippocrates, the Father of modern medicine. #blogpost

Multisensory gamma stimulation promotes glymphatic clearance of amyloid Non invasive Brainstimulation. A recently puplished article from Mitchell H. Murdock et al. in nature. The authors show that multisensory gamma stimulation promotes the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of Alzheimer’s disease. Their findings establish novel mechanisms that recruit the glymphatic system to remove brain amyloid. https://lnkd.in/g3BjkCNc Specifically, brain rhythms at gamma frequency can be evoked by means of noninvasive stimulation—such as sound, light, magnetic, or low intensity electrical currents delivered between 30 and 50 Hz—and induce beneficial effects in the AD brain. #Alzheimer #Brainstimulation #Amyloid

Take a first look at Nova Heart, a very practical and valuable application of a digital twin.