📣 Recent work has shown that molecularly-defined DA subtypes within the substantia nigra (SNc) display distinctive anatomic and functional properties, and differential vulnerability in #ParkinsonsDisease. To develop a more granular map, Team Awatramani used single-nuclear RNA sequencing to reveal three main families and twenty molecularly distinct DA neuron subtypes. Learn more: https://lnkd.in/eFY9Dw5i
Aligning Science Across Parkinson’s | ASAP
Research Services
ASAP is a global research initiative accelerating the pace of discovery for #ParkinsonsDisease.
About us
ASAP is a global research initiative accelerating the pace of discovery for #ParkinsonsDisease. We do this through collaboration, resource generation, and data sharing. #openscience. Follow us on Bluesky @asapresearch.bsky.social.
- Website
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https://parkinsonsroadmap.org/
External link for Aligning Science Across Parkinson’s | ASAP
- Industry
- Research Services
- Company size
- 11-50 employees
- Headquarters
- Washington, D.C.
- Type
- Partnership
- Founded
- 2020
Locations
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Primary
Washington, D.C., US
Employees at Aligning Science Across Parkinson’s | ASAP
Updates
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📣 Recent evidence supports that phosphorylation of αSyn at serine 129 (PSER129) is present in non-diseased mammalian brains. Team Kordower reports that pretreating tissue with calf alkaline phosphatase allowed for differentiation between pathological and normal physiological PSER129. Check out Team Kordower's recent publication to read more about their findings. https://bit.ly/3WdVoIV
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New Job Alert! 🚨 Xianjun Dong's lab (Team Scherzer) at Yale University is hiring for multiple positions at various levels, including Postdoctoral Fellows and a Research Scientist. If you have a PhD in bioinformatics, computer science, genomics, or neuroscience, apply today! For more information on open positions, visit: https://bit.ly/469eS5Q
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Are you a supervisor who belongs to an underrepresented group? Are your trainees passionate about #ParkinsonsDisease genetics research? If so, check out the GP2 Underrepresented Populations Program! As part of this program, GP2 offers funding for a PhD in Parkinson's disease #genetics or a related field. Funding supports the cost of a 3-year PhD studentship starting between October 2024 and May 2025. Supervisors should apply by Wednesday, July 31, 2024! Learn more: https://lnkd.in/ejnvaMd3
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🎉 Congratulations to the winners of the 2024 ASAP COSA Virtual Poster Symposium! In May, ASAP hosted the Celebration of Scientific Achievement (COSA) event, a three-day virtual poster symposium where members of the ASAP community are encouraged to exchange scientific ideas and foster new #collaborations. The COSA event provides an avenue to highlight trainee discoveries, along with the innovative and bold approaches that they are taking to tackle our understanding of #ParkinsonsDisease. This year, we were pleased to award prizes to 10 trainees for their outstanding presentations during the event. Learn more about the winners: https://lnkd.in/gi7vCRN5
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📣 Using cryo-electron tomography, Team Harper found an amorphous aggregate phase exists next to polyQ aggregates in cultured cells in-situ. Autophagosomes preferentially interacted with the amorphous phase, preventing interaction with the polyQ aggregates. Check out Team Harper's publication to read more about their findings. https://lnkd.in/eAu8Mh9F
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📣 Most cases of sporadic #ParkinsonsDisease are hypothesized to arise due to a complex interaction of genetics and environmental factors, such as the microbiome. To explore this hypothesis, Team Gradinaru and Team Sulzer generated germ-free ASO mice and found tissue-specific changes in metabolites driven by genotype, microbiome, and their interaction. Check out their preprint to read more about their findings: https://lnkd.in/gTHkh8j7
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This Team Tuesday, ASAP is highlighting Team Lee. Explore their team page and featured output which indicates that a loss of tau protein reduces disease progression and neurodegeneration in a synucleinopathy-based mouse model. #ParkinsonsDisease https://lnkd.in/gcVj_e-D
Team Lee
https://parkinsonsroadmap.org
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📣 Using a Drosophila model which expresses human alpha synuclein in neurons and allows for genetic manipulation of glial cells, Team Scherzer found disrupted glial adenosine metabolism may be a new potential therapeutic target for #ParkinsonsDisease. Check out Team Scherzer's latest preprint to read more about these findings. https://lnkd.in/d46MGkSm
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